Protein Summary
May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1).
- ENST00000325551
- ENSP00000320434
- ENSG00000119326
- ENST00000374595
- ENSP00000363723
- ACRP
- CLLP
- alpha-CATU
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
virus perturbation | 0.95 | ||
transcription factor perturbation | 0.91 | ||
kinase perturbation | 0.88 | ||
PubMedID | 0.85 | ||
gene perturbation | 0.8 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.15 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 133 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.15 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 133 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Pathways (22)
PathwayCommons (2)
WikiPathways (20)
Items per page:
1 – 2 of 2
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
PathwayCommons: panther | Wnt signaling pathway | ||||
PathwayCommons: netpath | EGFR1 | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Wnt signaling pathway | ||||
EGFR1 | ||||
Gene Ontology Terms (7)
Functions (2)
Components (3)
Processes (2)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (51)
1 – 10 of 51
DMD
Novelty: 0.00029078
p_int: 0.999999994
p_ni: 1e-9
p_wrong: 6e-9
Score: 0.789
Data Source: BioPlex,STRINGDB
SNTG2
Novelty: 0.02799688
p_int: 0.999999986
p_ni: 1.4e-8
Score: 0.822
Data Source: BioPlex,STRINGDB
SNTG1
Novelty: 0.03490951
p_int: 0.999999955
p_ni: 4.5e-8
Data Source: BioPlex
RPP25L
Family: Enzyme
p_int: 0.999995496
p_ni: 0.000004503
p_wrong: 1e-9
Data Source: BioPlex
LY6D
Novelty: 0.02107305
p_int: 0.999989393
p_ni: 0.000010607
Data Source: BioPlex
RNF135
Family: Enzyme
Novelty: 0.0446139
p_int: 0.999733949
p_ni: 0.000265989
p_wrong: 6.2e-8
Score: 0.247
Data Source: BioPlex,STRINGDB
RHPN1
Novelty: 0.11250959
p_int: 0.999633524
p_ni: 0.00036647
p_wrong: 6e-9
Score: 0.175
Data Source: BioPlex,STRINGDB
SPERT
Novelty: 0.04642166
p_int: 0.99961393
p_ni: 0.000383085
p_wrong: 0.000002985
Score: 0.221
Data Source: BioPlex,STRINGDB
TAGAP
Family: Enzyme
Novelty: 0.05422504
p_int: 0.99164263
p_ni: 0.00798828
p_wrong: 0.00036909
Data Source: BioPlex
IFT20
Novelty: 0.03992585
p_int: 0.990510167
p_ni: 0.008651355
p_wrong: 0.000838478
Data Source: BioPlex
Publication Statistics
PubMed Score 14.15
PubMed score by year
PubTator Score 9.86
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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