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Tbio
CTNNAL1
Alpha-catulin

Protein Summary
Description
May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325551
  • ENSP00000320434
  • ENSG00000119326
  • ENST00000374595
  • ENSP00000363723

Symbol
  • ACRP
  • CLLP
  • alpha-CATU
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
transcription factor perturbation
0.91
kinase perturbation
0.88
PubMedID
0.85
gene perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.15   (req: < 5)
View Publications
Gene RIFs: 17   (req: <= 3)
View Gene RIFs
Antibodies: 133   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.15   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
actin filament binding
Inferred from Electronic Annotation (IEA)
InterPro
cadherin binding
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (51)
1 – 10 of 51
DMD
Tclin
Novelty: 0.00029078
p_int: 0.999999994
p_ni: 1e-9
p_wrong: 6e-9
Score: 0.789
Data Source: BioPlex,STRINGDB
SNTG2
Tbio
Novelty: 0.02799688
p_int: 0.999999986
p_ni: 1.4e-8
Score: 0.822
Data Source: BioPlex,STRINGDB
SNTG1
Tbio
Novelty: 0.03490951
p_int: 0.999999955
p_ni: 4.5e-8
Data Source: BioPlex
RPP25L
Tdark
Family: Enzyme
p_int: 0.999995496
p_ni: 0.000004503
p_wrong: 1e-9
Data Source: BioPlex
LY6D
Tbio
Novelty: 0.02107305
p_int: 0.999989393
p_ni: 0.000010607
Data Source: BioPlex
RNF135
Tbio
Family: Enzyme
Novelty: 0.0446139
p_int: 0.999733949
p_ni: 0.000265989
p_wrong: 6.2e-8
Score: 0.247
Data Source: BioPlex,STRINGDB
RHPN1
Tbio
Novelty: 0.11250959
p_int: 0.999633524
p_ni: 0.00036647
p_wrong: 6e-9
Score: 0.175
Data Source: BioPlex,STRINGDB
SPERT
Tbio
Novelty: 0.04642166
p_int: 0.99961393
p_ni: 0.000383085
p_wrong: 0.000002985
Score: 0.221
Data Source: BioPlex,STRINGDB
TAGAP
Tbio
Family: Enzyme
Novelty: 0.05422504
p_int: 0.99164263
p_ni: 0.00798828
p_wrong: 0.00036909
Data Source: BioPlex
IFT20
Tbio
Novelty: 0.03992585
p_int: 0.990510167
p_ni: 0.008651355
p_wrong: 0.000838478
Data Source: BioPlex
Publication Statistics
PubMed Score  14.15

PubMed score by year
PubTator Score  9.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer