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Tbio
DKK4
Dickkopf-related protein 4

Protein Summary
Description
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000220812
  • ENSP00000220812
  • ENSG00000104371

Symbol
  • DKK-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.72
gene perturbation
0.68
cell line
0.64
disease
0.46
biological term
0.42


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.61   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 386   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.61   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 386   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (23)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Reactome
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Disease
Diseases of signal transduction
Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Signal Transduction
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (56)
1 – 10 of 56
RNPEPL1
Tbio
Family: Enzyme
Novelty: 0.03441194
p_int: 0.999999794
p_ni: 7e-9
p_wrong: 2e-7
Score: 0.549
Data Source: BioPlex,STRINGDB
LRP5
Tbio
Novelty: 0.00089807
p_int: 0.947660544
p_ni: 0.052339453
p_wrong: 3e-9
Score: 0.967
Data Source: BioPlex,STRINGDB
CUL1
Tbio
Novelty: 0.00244476
p_int: 0.792902533
p_ni: 0.207097467
Score: 0.213
Data Source: BioPlex,STRINGDB
IDE
Tchem
Family: Enzyme
Novelty: 0.00207793
p_int: 0.778327104
p_ni: 0.221672896
Score: 0.206
Data Source: BioPlex,STRINGDB
KREMEN1
Tbio
Novelty: 0.03616334
Score: 0.956
Data Source: STRINGDB
LRP6
Tbio
Novelty: 0.00305615
Score: 0.948
Data Source: STRINGDB
WNT3A
Tchem
Novelty: 0.00119275
Score: 0.944
Data Source: STRINGDB
FZD1
Tbio
Family: GPCR
Novelty: 0.01097201
Score: 0.943
Data Source: STRINGDB
WNT1
Tbio
Novelty: 0.00124301
Score: 0.942
Data Source: STRINGDB
KREMEN2
Tbio
Novelty: 0.07650397
Score: 0.942
Data Source: STRINGDB
Publication Statistics
PubMed Score  37.61

PubMed score by year
PubTator Score  31.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer