UBA2
SUMO-activating enzyme subunit 2
Protein Summary
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]
- ENST00000246548
- ENSP00000246548
- ENSG00000126261
- ENST00000439527
- ENSP00000437484
- SAE2
- UBLE1B
- ARX
- SAE2
- HRIHFB2115
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug perturbation | 0.99 | ||
co-expressed gene | 0.98 | ||
molecular function | 0.97 | ||
protein domain | 0.97 | ||
disease perturbation | 0.87 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 75.15 (req: < 5)
Gene RIFs: 22 (req: <= 3)
Antibodies: 323 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 75.15 (req: >= 5)
Gene RIFs: 22 (req: > 3)
Antibodies: 323 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0