UBA2
SUMO-activating enzyme subunit 2
Protein Summary
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]
- ENST00000246548
- ENSP00000246548
- ENSG00000126261
- ENST00000439527
- ENSP00000437484
- SAE2
- UBLE1B
- ARX
- SAE2
- HRIHFB2115
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug perturbation | 0.99 | ||
co-expressed gene | 0.98 | ||
molecular function | 0.97 | ||
protein domain | 0.97 | ||
disease perturbation | 0.87 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 65.88 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 323 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 65.88 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 323 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (227)
UBE2I
Novelty: 0.00267883
p_int: 0.999996656
p_ni: 0.000003344
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SAE1
Novelty: 0.01613881
p_int: 0.999962977
p_ni: 0.000037023
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CPNE5
Novelty: 0.09416684
p_int: 0.970635722
p_ni: 0.029364278
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (9)
Reactome (6)
KEGG (1)
PathwayCommons (1)
UniProt (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational protein modification | ||||
Reactome | Processing and activation of SUMO | ||||
Reactome | SUMO is conjugated to E1 (UBA2:SAE1) | ||||
Reactome | SUMO is transferred from E1 to E2 (UBE2I, UBC9) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of proteins | ||||
Post-translational protein modification | ||||
Processing and activation of SUMO | ||||
SUMO is conjugated to E1 (UBA2:SAE1) | ||||
SUMO is transferred from E1 to E2 (UBE2I, UBC9) | ||||
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (11)
Components (3)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
electrocardiography | 1 | 1 | 1 | 15.8 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
electrocardiography | 1 | 15.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ubiquitin like modifier activating enzyme 2 | VGNC:7494 | 468823 | |||||
Macaque | ubiquitin like modifier activating enzyme 2 | 705808 | ||||||
Mouse | MGI:1858313 | 50995 | ||||||
Rat | RGD:1312023 | 308508 | ||||||
Dog | ubiquitin like modifier activating enzyme 2 | VGNC:48037 | 476490 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ubiquitin like modifier activating enzyme 2 | |||||
Macaque | ubiquitin like modifier activating enzyme 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ubiquitin like modifier activating enzyme 2 | |||||
Publication Statistics
PubMed Score 65.88
PubMed score by year
PubTator Score 41.86
PubTator score by year
Related Publications
Text Mined References (36)
GeneRif Annotations (12)
Items per page:
0 of 0
PMID | Year | Title |
|---|