Tbio UBA2 SUMO-activating enzyme subunit 2

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Sumo-activating Enzyme Subunit 2

Protein / Ligase / Sumo-activating Enzyme Subunit 2

Protein Summary

Description

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]

Uniprot Accession IDs

• Q9UBT2
• B3KWB9
• O95605
• Q59H87
• Q6IBP6
• Q9NTJ1
• Q9UED2

Gene Name

• UBA2

Ensembl ID

• ENST00000246548
• ENSP00000246548
• ENSG00000126261
• ENST00000439527
• ENSP00000437484

Symbol

• SAE2
• UBLE1B
• ARX
• SAE2
• HRIHFB2115

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.99
co-expressed gene	0.98
molecular function	0.97
protein domain	0.97
disease perturbation	0.87

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.35   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 323   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.35   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 323   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (7)

1 – 5 of 7

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (9)

Reactome (6)

KEGG (1)

PathwayCommons (1)

UniProt (1)

Metabolism of proteins (R-HSA-392499)

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5

1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Post-translational protein modification	1450 targets	R-HSA-597592
Reactome	Processing and activation of SUMO	10 targets	R-HSA-3215018
Reactome	SUMO is conjugated to E1 (UBA2:SAE1)	5 targets	R-HSA-3065676
Reactome	SUMO is transferred from E1 to E2 (UBE2I, UBC9)	7 targets	R-HSA-3065678

Name	Explore in Pharos	Explore in Source
Metabolism of proteins	2050 targets	R-HSA-392499
Post-translational protein modification	1450 targets	R-HSA-597592
Processing and activation of SUMO	10 targets	R-HSA-3215018
SUMO is conjugated to E1 (UBA2:SAE1)	5 targets	R-HSA-3065676
SUMO is transferred from E1 to E2 (UBE2I, UBC9)	7 targets	R-HSA-3065678

Gene Ontology Terms (15)

Functions (11)

Components (3)

Processes (1)

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Items per page:

10

1 – 10 of 11

GO Term	Evidence	Assigned by
SUMO activating enzyme activity	Inferred from Direct Assay (IDA)	UniProtKB
small protein activating enzyme binding	Inferred from Physical Interaction (IPI)	CAFA
SUMO binding	Inferred from Physical Interaction (IPI)	CAFA
ubiquitin-like protein conjugating enzyme binding	Inferred from Physical Interaction (IPI)	CAFA
ATP binding	Inferred from Mutant Phenotype (IMP)	CAFA
magnesium ion binding	Inferred from Mutant Phenotype (IMP)	CAFA
protein heterodimerization activity	Inferred from Mutant Phenotype (IMP)	CAFA
enzyme activator activity	Traceable Author Statement (TAS)	ProtInc
acid-amino acid ligase activity	Inferred from Electronic Annotation (IEA)	InterPro
transcription factor binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (227)

Explore Interacting Targets

1 – 10 of 227

• See Interactions on String-DB

UBE2I

Tbio

Novelty: 0.00316288

p_int: 0.999996656

p_ni: 0.000003344

Score: 0.999

Data Source: BioPlex,Reactome,STRINGDB

SAE1

Tbio

Novelty: 0.02519067

p_int: 0.999962977

p_ni: 0.000037023

Score: 0.999

Data Source: BioPlex,Reactome,STRINGDB

CPNE5

Tbio

Novelty: 0.17144272

p_int: 0.970635722

p_ni: 0.029364278

Score: 0.189

Data Source: BioPlex,STRINGDB

SUMO1

Tbio

Novelty: 0.00169202

Score: 0.999

Data Source: Reactome,STRINGDB

SUMO2

Tbio

Novelty: 0.00437464

Score: 0.995

Data Source: Reactome,STRINGDB

SUMO3

Tbio

Novelty: 0.0468487

Score: 0.991

Data Source: Reactome,STRINGDB

RWDD3

Tbio

Novelty: 0.09534715

Score: 0.923

Data Source: STRINGDB

SUMO4

Tbio

Novelty: 0.01875074

Score: 0.914

Data Source: STRINGDB

SENP1

Tchem

Family: Enzyme

Novelty: 0.00919181

Score: 0.876

Data Source: STRINGDB

UBE2M

Tbio

Novelty: 0.03835215

Score: 0.873

Data Source: STRINGDB

Publication Statistics

PubMed Score  37.35

PubMed score by year

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PubTator Score  41.86

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Acetylation
Alternative splicing
ATP-binding
Complete proteome
Cytoplasm
Isopeptide bond
Metal-binding
Nucleotide-binding
Nucleus

MGI Phenotype Find Similar Targets

mortality/aging