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Tbio
RNF14
E3 ubiquitin-protein ligase RNF14

Protein Summary
Description
Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription. The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347642
  • ENSP00000324956
  • ENSG00000013561
  • ENST00000356143
  • ENSP00000348462
  • ENST00000394514
  • ENSP00000378022
  • ENST00000394519
  • ENSP00000378027
  • ENST00000394520
  • ENSP00000378028

Symbol
  • ARA54
  • ARA54
  • HFB30
  • TRIAD2
  • HRIHFB2038
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
kinase perturbation
0.95
virus perturbation
0.94
disease perturbation
0.87
molecular function
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.16   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 231   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.16   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 231   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
54.4
insomnia measurement
1
1
0
1
44.2
myeloid white cell count
1
1
1
15.4
1
1
0
1
12.9
sum of basophil and neutrophil counts
1
1
1
12.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
54.4
insomnia measurement
0
1
44.2
myeloid white cell count
1
15.4
0
1
12.9
sum of basophil and neutrophil counts
1
12.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 14
VGNC:4150
471678
Macaque
ring finger protein 14
705363
Mouse
MGI:1929668
56736
Rat
RGD:1589576
619577
Dog
ring finger protein 14
VGNC:45633
478042
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 14
Macaque
ring finger protein 14
Mouse
Rat
Dog
ring finger protein 14
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UBS8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (110)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Gene Ontology Terms (20)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (318)
1 – 10 of 318
VTN
Tbio
Family:  TF
Novelty:  0.00046861
p_int:  0.998447406
p_ni:  0.001550503
p_wrong:  0.000002091
Score:  0.214
Data Source:  BioPlex,STRINGDB
UBE2W
Tbio
Novelty:  0.07255713
p_int:  0.998330637
p_ni:  0.000285674
p_wrong:  0.001383689
Score:  0.913
Data Source:  BioPlex,STRINGDB
SPANXN4
Tdark
Novelty:  1.91062423
p_int:  0.994279312
p_ni:  0.002250721
p_wrong:  0.003469967
Data Source:  BioPlex
RNF6
Tbio
Family:  Enzyme
Novelty:  0.06214038
Score:  0.97
Data Source:  STRINGDB
UBE2E2
Tbio
Novelty:  0.02752227
Score:  0.953
Data Source:  STRINGDB
RNF138
Tbio
Family:  TF
Novelty:  0.07543428
Score:  0.951
Data Source:  STRINGDB
UBE2E3
Tbio
Novelty:  0.03477232
Score:  0.948
Data Source:  STRINGDB
UBE2E1
Tbio
Novelty:  0.04048768
Score:  0.943
Data Source:  STRINGDB
UBE2L6
Tbio
Novelty:  0.03471633
Score:  0.94
Data Source:  STRINGDB
UBE2D1
Tbio
Novelty:  0.00865867
Score:  0.934
Data Source:  STRINGDB
Publication Statistics
PubMed Score  16.16

PubMed score by year
PubTator Score  11.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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