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Tclin
GABBR1
Gamma-aminobutyric acid type B receptor subunit 1

Protein Summary
Description
Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10906333, PubMed:10773016, PubMed:10075644, PubMed:9872744, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644). Calcium is required for high affinity binding to GABA (By similarity). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9844003). Pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355973
  • ENSP00000348248
  • ENSG00000204681
  • ENST00000376977
  • ENSP00000366176
  • ENST00000377012
  • ENSP00000366211
  • ENST00000377016
  • ENSP00000366215
  • ENST00000377034
  • ENSP00000366233
  • ENST00000383537
  • ENSP00000373029
  • ENSG00000206466
  • ENST00000383541
  • ENSP00000373033
  • ENST00000383542
  • ENSP00000373034
  • ENST00000383543
  • ENSP00000373035
  • ENST00000383636
  • ENSP00000373132
  • ENSG00000206511
  • ENST00000383637
  • ENSP00000373133
  • ENST00000383638
  • ENSP00000373134
  • ENST00000383639
  • ENSP00000373135
  • ENST00000414980
  • ENSP00000406499
  • ENSG00000232632
  • ENST00000417759
  • ENSP00000391572
  • ENSG00000237112
  • ENST00000419674
  • ENSP00000399861
  • ENSG00000232569
  • ENST00000423604
  • ENSP00000388035
  • ENST00000425097
  • ENSP00000411286
  • ENST00000434660
  • ENSP00000412167
  • ENST00000438094
  • ENSP00000406285
  • ENST00000439457
  • ENSP00000406066
  • ENST00000443440
  • ENSP00000399318
  • ENST00000446436
  • ENSP00000394528
  • ENST00000448754
  • ENSP00000405709
  • ENSG00000237051
  • ENST00000449163
  • ENSP00000411263
  • ENST00000452300
  • ENSP00000408938
  • ENST00000458612
  • ENSP00000416903
  • ENST00000494877
  • ENSP00000419061
  • ENST00000546913
  • ENSP00000448999
  • ENST00000547410
  • ENSP00000448531
  • ENST00000548767
  • ENSP00000446983
  • ENST00000551140
  • ENSP00000448654
  • ENST00000551423
  • ENSP00000449342
  • ENST00000552399
  • ENSP00000449449

Symbol
  • GPRC3A
  • GB1
  • GPRC3A
  • GABABR1
  • GABBR1-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.92
hub protein
0.85
protein domain
0.85
phenotype
0.69
transcription factor perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1096.33   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 510   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1096.33   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 510   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (77)
Items per page:
1 – 5 of 77
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
3
4
3
1.1
93.5
unipolar depression
3
4
3
1.1
93.5
unipolar depression
3
4
3
1.1
93.5
unipolar depression
3
4
3
1.1
93.5
unipolar depression
3
4
3
1.1
93.5
Items per page:
1 – 5 of 77
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
3
1.1
93.5
unipolar depression
3
1.1
93.5
unipolar depression
3
1.1
93.5
unipolar depression
3
1.1
93.5
unipolar depression
3
1.1
93.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1860139
54393
Rat
RGD:621537
81657
Dog
gamma-aminobutyric acid type B receptor subunit 1
VGNC:41048
488340
Cow
gamma-aminobutyric acid type B receptor subunit 1
VGNC:29187
513785
Opossum
gamma-aminobutyric acid type B receptor subunit 1
100023559
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
gamma-aminobutyric acid type B receptor subunit 1
Cow
gamma-aminobutyric acid type B receptor subunit 1
Opossum
gamma-aminobutyric acid type B receptor subunit 1
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UBS5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (35)
Activation of G protein gated Potassium channels (R-HSA-1296041)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of G protein gated Potassium channels
Reactome
Activation of GABAB receptors
Reactome
Class C/3 (Metabotropic glutamate/pheromone receptors)
Reactome
G alpha (i) signalling events
Reactome
G protein gated Potassium channels
Name
Explore in Pharos
Explore in Source
Activation of G protein gated Potassium channels
Activation of GABAB receptors
Class C/3 (Metabotropic glutamate/pheromone receptors)
G alpha (i) signalling events
G protein gated Potassium channels
Protein-Protein Interactions (391)
1 – 10 of 391
MTFR2
Tbio
Novelty: 0.20272025
p_int: 0.99997012
p_ni: 0.000004486
p_wrong: 0.000025394
Data Source: BioPlex
PPP1R12A
Tbio
Family: Enzyme
Novelty: 0.0028297
p_int: 0.999937003
p_ni: 0.000061753
p_wrong: 0.000001244
Data Source: BioPlex
GOLGA5
Tbio
Novelty: 0.04940885
p_int: 0.992920709
p_ni: 0.007079291
Data Source: BioPlex
MFSD8
Tbio
Novelty: 0.03388459
p_int: 0.98208055
p_ni: 0.005033351
p_wrong: 0.012886099
Data Source: BioPlex
ORMDL2
Tdark
Novelty: 0.37598406
p_int: 0.927878649
p_ni: 0.010601998
p_wrong: 0.061519353
Data Source: BioPlex
MTFR1
Tbio
Novelty: 0.14089765
p_int: 0.916667231
p_ni: 0.083331593
p_wrong: 0.000001176
Data Source: BioPlex
ZDHHC17
Tbio
Family: Enzyme
Novelty: 0.03288707
p_int: 0.900006539
p_ni: 0.099993196
p_wrong: 2.65e-7
Data Source: BioPlex
TPD52L1
Tbio
Novelty: 0.04828057
p_int: 0.891587447
p_ni: 0.108408205
p_wrong: 0.000004348
Data Source: BioPlex
ORMDL3
Tbio
Novelty: 0.00958976
p_int: 0.790244383
p_ni: 0.000257544
p_wrong: 0.209498073
Data Source: BioPlex
MYCBP2
Tbio
Family: Enzyme
Novelty: 0.00413684
p_int: 0.767009156
p_ni: 0.232990844
Data Source: BioPlex
Publication Statistics
PubMed Score  1096.33

PubMed score by year
PubTator Score  366.08

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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