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Tchem
RPS6KB2
Ribosomal protein S6 kinase beta-2

Protein Summary
Description
Phosphorylates specifically ribosomal protein S6. This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312629
  • ENSP00000308413
  • ENSG00000175634
  • ENST00000528964
  • ENSP00000432847

Symbol
  • STK14B
  • KLS
  • SRK
  • S6K2
  • S6KB
  • STK14B
  • S6KI(2)
  • S6Kbeta
  • p70S6Kb
  • P70-beta
  • S6K-beta2
  • P70-beta-1
  • P70-beta-2
  • p70(S6K)-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
0.98
protein domain
0.97
molecular function
0.94
co-expressed gene
0.87
interacting protein
0.87


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.92   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 719   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.92   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 719   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
staurosporine
Rendered image for staurosporine
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
3
3
94.9
body height
2
2
2
94.5
mean corpuscular volume
2
3
3
94
mean corpuscular hemoglobin concentration
2
2
2
89
IGF-1 measurement
1
2
2
65.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
3
94.9
body height
2
94.5
mean corpuscular volume
3
94
mean corpuscular hemoglobin concentration
2
89
IGF-1 measurement
2
65.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S6 kinase B2
VGNC:8306
746903
Macaque
ribosomal protein S6 kinase B2
721731
Mouse
MGI:1927343
58988
Rat
RGD:1305144
361696
Dog
ribosomal protein S6 kinase B2
VGNC:45745
610499
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S6 kinase B2
Macaque
ribosomal protein S6 kinase B2
Mouse
Rat
Dog
ribosomal protein S6 kinase B2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UBS0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (95)
AKT phosphorylates targets in the nucleus (R-HSA-198693)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AKT phosphorylates targets in the nucleus
Reactome
Constitutive Signaling by AKT1 E17K in Cancer
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Intracellular signaling by second messengers
Name
Explore in Pharos
Explore in Source
AKT phosphorylates targets in the nucleus
Constitutive Signaling by AKT1 E17K in Cancer
Disease
Diseases of signal transduction
Intracellular signaling by second messengers
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (97)
1 – 10 of 97
CEP76
Tdark
Novelty:  0.3880387
p_int:  0.999979938
p_ni:  0.000020062
Data Source:  BioPlex
HSP90AA5P
Tdark
p_int:  0.99991752
p_ni:  0.00008248
Data Source:  BioPlex
FKBP5
Tchem
Family:  Enzyme
Novelty:  0.00214511
p_int:  0.93697265
p_ni:  0.063027349
Data Source:  BioPlex
HSP90AB1
Tchem
Novelty:  0.00907961
p_int:  0.827877997
p_ni:  0.172122003
Data Source:  BioPlex
RPS6
Tbio
Novelty:  0.00122241
Score:  0.996
Data Source:  STRINGDB
MTOR
Tclin
Family:  Kinase
Novelty:  0.00012333
Score:  0.991
Data Source:  STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.98
Data Source:  STRINGDB
RPTOR
Tbio
Novelty:  0.00119147
Score:  0.971
Data Source:  STRINGDB
IRS1
Tchem
Novelty:  0.00048281
Score:  0.956
Data Source:  STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.944
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  42.92

PubMed score by year
PubTator Score  103.1

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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