Tchem RPS6KB2 Ribosomal protein S6 kinase beta-2

Protein Summary

Description

Phosphorylates specifically ribosomal protein S6. This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015]

Uniprot Accession IDs

• Q9UBS0
• B2RMZ9
• B4DML8
• O94809
• Q9UEC1
• S6K-beta-2

Gene Name

• RPS6KB2

Ensembl ID

• ENST00000312629
• ENSP00000308413
• ENSG00000175634
• ENST00000528964
• ENSP00000432847

Symbol

• STK14B
• KLS
• SRK
• S6K2
• S6KB
• STK14B
• S6KI(2)
• S6Kbeta
• p70S6Kb
• P70-beta
• S6K-beta2
• P70-beta-1
• P70-beta-2
• p70(S6K)-beta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase	0.98
protein domain	0.97
molecular function	0.94
co-expressed gene	0.87
interacting protein	0.87

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Agc Group / Rsk Family / P70 Subfamily / Ribosomal Protein S6 Kinase Beta-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.68   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 719   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.68   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 719   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0