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Tchem
RPS6KB2
Ribosomal protein S6 kinase beta-2

Protein Summary
Description
Phosphorylates specifically ribosomal protein S6. This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312629
  • ENSP00000308413
  • ENSG00000175634
  • ENST00000528964
  • ENSP00000432847

Symbol
  • STK14B
  • KLS
  • SRK
  • S6K2
  • S6KB
  • STK14B
  • S6KI(2)
  • S6Kbeta
  • p70S6Kb
  • P70-beta
  • S6K-beta2
  • P70-beta-1
  • P70-beta-2
  • p70(S6K)-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
0.98
protein domain
0.97
molecular function
0.94
co-expressed gene
0.87
interacting protein
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.68   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 719   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.68   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 719   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0