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Tbio
LHX3
LIM/homeobox protein Lhx3

Protein Summary
Description
Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1. This gene encodes a member of a large family of proteins which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Mutations in this gene cause combined pituitary hormone deficiency 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371746
  • ENSP00000360811
  • ENSG00000107187
  • ENST00000371748
  • ENSP00000360813

Symbol
  • LIM3
  • CPHD3
  • M2-LHX3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.75
cell type or tissue
0.72
protein domain
0.58
tissue
0.58
cellular component
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.61   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.61   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hormone measurement
1
1
3
73
vital capacity
1
1
1
66.8
sex hormone-binding globulin measurement
4
1
4
64.2
red blood cell density measurement
1
1
1
59.8
1
1
0
1.1
44.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hormone measurement
3
73
vital capacity
1
66.8
sex hormone-binding globulin measurement
4
64.2
red blood cell density measurement
1
59.8
0
1.1
44.7
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LIM homeobox 3
VGNC:4779
746333
Macaque
LIM homeobox 3
574165
Mouse
MGI:102673
16871
Rat
RGD:71078
170671
Dog
LIM homeobox 3
VGNC:42664
607584
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LIM homeobox 3
Macaque
LIM homeobox 3
Mouse
Rat
Dog
LIM homeobox 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UBR4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Regulation of expression of SLITs and ROBOs
Reactome
Signaling by ROBO receptors
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Regulation of expression of SLITs and ROBOs
Signaling by ROBO receptors
Gene Ontology Terms (22)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (111)
1 – 10 of 111
LDB1
Tbio
Novelty: 0.01110112
Score: 0.981
Data Source: Reactome,STRINGDB
ISL1
Tbio
Family: TF
Novelty: 0.00169431
Score: 0.966
Data Source: Reactome,STRINGDB
ROBO2
Tbio
Novelty: 0.00757203
Score: 0.912
Data Source: STRINGDB
SLIT2
Tbio
Novelty: 0.00710401
Score: 0.911
Data Source: STRINGDB
ROBO1
Tbio
Novelty: 0.00494884
Score: 0.905
Data Source: STRINGDB
LHX4
Tbio
Family: TF
Novelty: 0.02047732
Score: 0.903
Data Source: STRINGDB
DAG1
Tbio
Family: Enzyme
Novelty: 0.00149278
Score: 0.9
Data Source: STRINGDB
POU1F1
Tbio
Family: TF
Novelty: 0.0052029
Score: 0.885
Data Source: STRINGDB
TBX19
Tbio
Family: TF
Novelty: 0.01599679
Score: 0.814
Data Source: STRINGDB
ESX1
Tbio
Family: TF
Novelty: 0.00330753
Score: 0.786
Data Source: STRINGDB
Publication Statistics
PubMed Score  124.61

PubMed score by year
PubTator Score  60.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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