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Tchem
CTSZ
Cathepsin Z

Protein Summary
Description
Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity. The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217131
  • ENSP00000217131
  • ENSG00000101160

Symbol
  • CTSX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
0.88
small molecule perturbation
0.84
transcription factor
0.7
cellular component
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.42   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 348   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.42   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 348   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
5
10
13
99.6
platelet count
6
8
9
18.6
98.6
platelet crit
1
2
2
95.9
reticulocyte count
2
1
2
78.3
blood urea nitrogen measurement
3
3
3
73.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
13
99.6
platelet count
9
18.6
98.6
platelet crit
2
95.9
reticulocyte count
2
78.3
blood urea nitrogen measurement
3
73.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cathepsin Z
VGNC:6087
736240
Macaque
cathepsin Z
694157
Mouse
MGI:1891190
64138
Rat
RGD:708479
252929
Dog
cathepsin Z
VGNC:39717
611983
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cathepsin Z
Macaque
cathepsin Z
Mouse
Rat
Dog
cathepsin Z
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UBR2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
Cargo concentration in the ER
Reactome
ER to Golgi Anterograde Transport
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
Cargo concentration in the ER
ER to Golgi Anterograde Transport
Immune System
Protein-Protein Interactions (195)
1 – 10 of 195
CTSD
Tchem
Family:  Enzyme
Novelty:  0.00029823
Score:  0.965
Data Source:  STRINGDB
MCFD2
Tbio
Novelty:  0.0402944
Score:  0.954
Data Source:  STRINGDB
LMAN1
Tbio
Novelty:  0.00595367
Score:  0.946
Data Source:  Reactome,STRINGDB
LMAN2L
Tbio
Novelty:  0.04364985
Score:  0.941
Data Source:  STRINGDB
LMAN2
Tbio
Novelty:  0.02922729
Score:  0.939
Data Source:  STRINGDB
CTSC
Tchem
Family:  Enzyme
Novelty:  0.00119917
Score:  0.929
Data Source:  STRINGDB
GGH
Tchem
Family:  Enzyme
Novelty:  0.00258239
Score:  0.927
Data Source:  STRINGDB
SERPINA1
Tbio
Novelty:  0.00014098
Score:  0.925
Data Source:  STRINGDB
SEC22A
Tdark
Novelty:  0.44427127
Score:  0.923
Data Source:  STRINGDB
AP1S1
Tbio
Novelty:  0.01740202
Score:  0.922
Data Source:  STRINGDB
Publication Statistics
PubMed Score  110.42

PubMed score by year
PubTator Score  55.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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