Protein Classes
Protein Summary
Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity. The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008]
- ENST00000217131
- ENSP00000217131
- ENSG00000101160
- CTSX
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
transcription factor perturbation | 0.88 | ||
small molecule perturbation | 0.84 | ||
transcription factor | 0.7 | ||
cellular component | 0.64 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 110.42 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 348 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 110.42 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 348 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (3)
1 – 3 of 3
GWAS Traits (22)
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 5 | 10 | 13 | 99.6 | |||||
platelet count | 6 | 8 | 9 | 18.6 | 98.6 | ||||
platelet crit | 1 | 2 | 2 | 95.9 | |||||
reticulocyte count | 2 | 1 | 2 | 78.3 | |||||
blood urea nitrogen measurement | 3 | 3 | 3 | 73.8 | |||||
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 13 | 99.6 | |||||
platelet count | 9 | 18.6 | 98.6 | ||||
platelet crit | 2 | 95.9 | |||||
reticulocyte count | 2 | 78.3 | |||||
blood urea nitrogen measurement | 3 | 73.8 | |||||
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cathepsin Z | VGNC:6087 | 736240 | |||||
Macaque | cathepsin Z | 694157 | ||||||
Mouse | MGI:1891190 | 64138 | ||||||
Rat | RGD:708479 | 252929 | ||||||
Dog | cathepsin Z | VGNC:39717 | 611983 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cathepsin Z | |||||
Macaque | cathepsin Z | |||||
Mouse | ||||||
Rat | ||||||
Dog | cathepsin Z | |||||
Protein Structure (2 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 2 of 2
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (18)
Reactome (16)
KEGG (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 16
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | COPII-mediated vesicle transport | ||||
Reactome | Cargo concentration in the ER | ||||
Reactome | ER to Golgi Anterograde Transport | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Asparagine N-linked glycosylation | ||||
COPII-mediated vesicle transport | ||||
Cargo concentration in the ER | ||||
ER to Golgi Anterograde Transport | ||||
Immune System | ||||
Gene Ontology Terms (34)
Functions (3)
Components (18)
Processes (13)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Protein-Protein Interactions (195)
1 – 10 of 195
CTSD
Family: Enzyme
Novelty: 0.00029823
Score: 0.965
Data Source: STRINGDB
MCFD2
Novelty: 0.0402944
Score: 0.954
Data Source: STRINGDB
LMAN1
Novelty: 0.00595367
Score: 0.946
Data Source: Reactome,STRINGDB
LMAN2L
Novelty: 0.04364985
Score: 0.941
Data Source: STRINGDB
LMAN2
Novelty: 0.02922729
Score: 0.939
Data Source: STRINGDB
CTSC
Family: Enzyme
Novelty: 0.00119917
Score: 0.929
Data Source: STRINGDB
GGH
Family: Enzyme
Novelty: 0.00258239
Score: 0.927
Data Source: STRINGDB
SERPINA1
Novelty: 0.00014098
Score: 0.925
Data Source: STRINGDB
SEC22A
Novelty: 0.44427127
Score: 0.923
Data Source: STRINGDB
AP1S1
Novelty: 0.01740202
Score: 0.922
Data Source: STRINGDB
Publication Statistics
PubMed Score 110.42
PubMed score by year
PubTator Score 55.68
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by:
UniProt Keyword
No Header | No Header | ||
|---|---|---|---|