Protein Summary
Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity. The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008]
- ENST00000217131
- ENSP00000217131
- ENSG00000101160
- CTSX
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
transcription factor perturbation | 0.88 | ||
small molecule perturbation | 0.84 | ||
transcription factor | 0.7 | ||
cellular component | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 110.42 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 348 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 110.42 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 348 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (3)
Protein-Protein Interactions (195)
Nearest Tclin Targets
Pathways (18)
Reactome (16)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | COPII-mediated vesicle transport | ||||
Reactome | Cargo concentration in the ER | ||||
Reactome | ER to Golgi Anterograde Transport | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Asparagine N-linked glycosylation | ||||
COPII-mediated vesicle transport | ||||
Cargo concentration in the ER | ||||
ER to Golgi Anterograde Transport | ||||
Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (34)
Functions (3)
Components (18)
Processes (13)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (22)
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 5 | 10 | 13 | 99.6 | |||||
platelet count | 6 | 8 | 9 | 18.6 | 98.6 | ||||
platelet crit | 1 | 2 | 2 | 95.9 | |||||
reticulocyte count | 2 | 1 | 2 | 78.3 | |||||
blood urea nitrogen measurement | 3 | 3 | 3 | 73.8 | |||||
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 13 | 99.6 | |||||
platelet count | 9 | 18.6 | 98.6 | ||||
platelet crit | 2 | 95.9 | |||||
reticulocyte count | 2 | 78.3 | |||||
blood urea nitrogen measurement | 3 | 73.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cathepsin Z | VGNC:6087 | 736240 | |||||
Macaque | cathepsin Z | 694157 | ||||||
Mouse | MGI:1891190 | 64138 | ||||||
Rat | RGD:708479 | 252929 | ||||||
Dog | cathepsin Z | VGNC:39717 | 611983 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cathepsin Z | |||||
Macaque | cathepsin Z | |||||
Mouse | ||||||
Rat | ||||||
Dog | cathepsin Z | |||||
Publication Statistics
PubMed Score 110.42
PubMed score by year
PubTator Score 55.68
PubTator score by year
Related Publications
Text Mined References (45)
GeneRif Annotations (19)
Items per page:
0 of 0
PMID | Year | Title |
|---|