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Tbio
UPB1
Beta-ureidopropionase

Protein Classes
Protein Summary
Description
Converts N-carbamoyl-beta-aminoisobutyrate and N-carbamoyl-beta-alanine (3-ureidopropanoate) to, respectively, beta-aminoisobutyrate and beta-alanine, ammonia and carbon dioxide. This gene encodes a protein that belongs to the CN hydrolase family. Beta-ureidopropionase catalyzes the last step in the pyrimidine degradation pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta-aminoisobutyric acid, respectively. UP deficiencies are associated with N-carbamyl-beta-amino aciduria and may lead to abnormalities in neurological activity. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326010
  • ENSP00000324343
  • ENSG00000100024

Symbol
  • BUP1
  • BUP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.81
kinase perturbation
0.66
transcription factor
0.63
cell line
0.57
tissue sample
0.53


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.63   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.63   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
beta-ureidopropionase 1
VGNC:10415
747532
Macaque
beta-ureidopropionase 1
707752
Mouse
MGI:2143535
103149
Dog
beta-ureidopropionase 1
VGNC:48149
486398
Horse
beta-ureidopropionase 1
VGNC:24803
100053177
Species
Name
OMA
EggNOG
Inparanoid
Chimp
beta-ureidopropionase 1
Macaque
beta-ureidopropionase 1
Mouse
Dog
beta-ureidopropionase 1
Horse
beta-ureidopropionase 1
Pathways (26)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase catabolism
Reactome
Pyrimidine catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase catabolism
Pyrimidine catabolism
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (68)
1 – 10 of 68
DPYS
Tbio
Family: Enzyme
Novelty: 0.01272377
Score: 0.989
Data Source: STRINGDB
AGXT2
Tbio
Family: Enzyme
Novelty: 0.02018289
Score: 0.985
Data Source: STRINGDB
DPYD
Tclin
Family: Enzyme
Novelty: 0.00207216
Score: 0.982
Data Source: STRINGDB
ABAT
Tclin
Family: Enzyme
Novelty: 0.0078359
Score: 0.927
Data Source: STRINGDB
ALDH9A1
Tbio
Family: Enzyme
Novelty: 0.01688006
Score: 0.925
Data Source: STRINGDB
CNDP2
Tbio
Family: Enzyme
Novelty: 0.00157228
Score: 0.917
Data Source: STRINGDB
GAD2
Tbio
Family: Enzyme
Novelty: 0.00058427
Score: 0.917
Data Source: STRINGDB
CNDP1
Tbio
Family: Enzyme
Novelty: 0.0102642
Score: 0.917
Data Source: STRINGDB
ALDH1B1
Tbio
Family: Enzyme
Novelty: 0.01755208
Score: 0.914
Data Source: STRINGDB
ALDH2
Tclin
Family: Enzyme
Novelty: 0.00077122
Score: 0.914
Data Source: STRINGDB
Publication Statistics
PubMed Score  55.63

PubMed score by year
PubTator Score  34.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer