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Tbio
UPB1
Beta-ureidopropionase

Protein Summary
Description
Converts N-carbamoyl-beta-aminoisobutyrate and N-carbamoyl-beta-alanine (3-ureidopropanoate) to, respectively, beta-aminoisobutyrate and beta-alanine, ammonia and carbon dioxide. This gene encodes a protein that belongs to the CN hydrolase family. Beta-ureidopropionase catalyzes the last step in the pyrimidine degradation pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta-aminoisobutyric acid, respectively. UP deficiencies are associated with N-carbamyl-beta-amino aciduria and may lead to abnormalities in neurological activity. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326010
  • ENSP00000324343
  • ENSG00000100024

Symbol
  • BUP1
  • BUP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.81
kinase perturbation
0.66
transcription factor
0.63
cell line
0.57
tissue sample
0.53


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.12   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.12   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
DPYS
Tbio
Family:  Enzyme
Novelty:  0.01272377
Score:  0.989
Data Source:  STRINGDB
AGXT2
Tbio
Family:  Enzyme
Novelty:  0.02018289
Score:  0.985
Data Source:  STRINGDB
DPYD
Tclin
Family:  Enzyme
Novelty:  0.00207216
Score:  0.982
Data Source:  STRINGDB
ABAT
Tclin
Family:  Enzyme
Novelty:  0.0078359
Score:  0.927
Data Source:  STRINGDB
ALDH9A1
Tbio
Family:  Enzyme
Novelty:  0.01688006
Score:  0.925
Data Source:  STRINGDB
CNDP2
Tbio
Family:  Enzyme
Novelty:  0.00157228
Score:  0.917
Data Source:  STRINGDB
GAD2
Tbio
Family:  Enzyme
Novelty:  0.00058427
Score:  0.917
Data Source:  STRINGDB
CNDP1
Tbio
Family:  Enzyme
Novelty:  0.0102642
Score:  0.917
Data Source:  STRINGDB
ALDH1B1
Tchem
Family:  Enzyme
Novelty:  0.01755208
Score:  0.914
Data Source:  STRINGDB
ALDH2
Tclin
Family:  Enzyme
Novelty:  0.00077122
Score:  0.914
Data Source:  STRINGDB
Pathways (26)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase catabolism
Reactome
Pyrimidine catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase catabolism
Pyrimidine catabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
8
19
20
9.5
99.9
tea consumption measurement
3
3
4
92.2
coffee consumption measurement
3
3
3
89.1
liver fibrosis measurement
1
1
1
82.3
protein measurement
1
1
1
72.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
20
9.5
99.9
tea consumption measurement
4
92.2
coffee consumption measurement
3
89.1
liver fibrosis measurement
1
82.3
protein measurement
1
72.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
beta-ureidopropionase 1
VGNC:10415
747532
Macaque
beta-ureidopropionase 1
707752
Mouse
MGI:2143535
103149
Dog
beta-ureidopropionase 1
VGNC:48149
486398
Horse
beta-ureidopropionase 1
VGNC:24803
100053177
Species
Name
OMA
EggNOG
Inparanoid
Chimp
beta-ureidopropionase 1
Macaque
beta-ureidopropionase 1
Mouse
Dog
beta-ureidopropionase 1
Horse
beta-ureidopropionase 1
Publication Statistics
PubMed Score 57.12
PubMed score by year
PubTator Score 34.45
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title