UPB1
Beta-ureidopropionase
Protein Summary
Converts N-carbamoyl-beta-aminoisobutyrate and N-carbamoyl-beta-alanine (3-ureidopropanoate) to, respectively, beta-aminoisobutyrate and beta-alanine, ammonia and carbon dioxide. This gene encodes a protein that belongs to the CN hydrolase family. Beta-ureidopropionase catalyzes the last step in the pyrimidine degradation pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta-aminoisobutyric acid, respectively. UP deficiencies are associated with N-carbamyl-beta-amino aciduria and may lead to abnormalities in neurological activity. [provided by RefSeq, Jul 2008]
- ENST00000326010
- ENSP00000324343
- ENSG00000100024
- BUP1
- BUP1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.81 | ||
kinase perturbation | 0.66 | ||
transcription factor | 0.63 | ||
cell line | 0.57 | ||
tissue sample | 0.53 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 57.12 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 87 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 57.12 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 87 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (68)
Nearest Tclin Targets (4)
Upstream (2)
Downstream (2)
1 – 2 of 2
Pathways (26)
Reactome (4)
KEGG (5)
PathwayCommons (4)
UniProt (1)
WikiPathways (12)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of nucleotides | ||||
Reactome | Nucleobase catabolism | ||||
Reactome | Pyrimidine catabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of nucleotides | ||||
Nucleobase catabolism | ||||
Pyrimidine catabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (2)
Components (2)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (24)
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 8 | 19 | 20 | 9.5 | 99.9 | ||||
tea consumption measurement | 3 | 3 | 4 | 92.2 | |||||
coffee consumption measurement | 3 | 3 | 3 | 89.1 | |||||
liver fibrosis measurement | 1 | 1 | 1 | 82.3 | |||||
protein measurement | 1 | 1 | 1 | 72.1 | |||||
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 20 | 9.5 | 99.9 | ||||
tea consumption measurement | 4 | 92.2 | |||||
coffee consumption measurement | 3 | 89.1 | |||||
liver fibrosis measurement | 1 | 82.3 | |||||
protein measurement | 1 | 72.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | beta-ureidopropionase 1 | VGNC:10415 | 747532 | |||||
Macaque | beta-ureidopropionase 1 | 707752 | ||||||
Mouse | MGI:2143535 | 103149 | ||||||
Dog | beta-ureidopropionase 1 | VGNC:48149 | 486398 | |||||
Horse | beta-ureidopropionase 1 | VGNC:24803 | 100053177 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | beta-ureidopropionase 1 | |||||
Macaque | beta-ureidopropionase 1 | |||||
Mouse | ||||||
Dog | beta-ureidopropionase 1 | |||||
Horse | beta-ureidopropionase 1 | |||||
Publication Statistics
PubMed Score 57.12
PubMed score by year
PubTator Score 34.45
PubTator score by year
Related Publications
Text Mined References (22)
GeneRif Annotations (9)
Items per page:
0 of 0
PMID | Year | Title |
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