UPB1
Beta-ureidopropionase
Protein Classes
Protein Summary
Converts N-carbamoyl-beta-aminoisobutyrate and N-carbamoyl-beta-alanine (3-ureidopropanoate) to, respectively, beta-aminoisobutyrate and beta-alanine, ammonia and carbon dioxide. This gene encodes a protein that belongs to the CN hydrolase family. Beta-ureidopropionase catalyzes the last step in the pyrimidine degradation pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta-aminoisobutyric acid, respectively. UP deficiencies are associated with N-carbamyl-beta-amino aciduria and may lead to abnormalities in neurological activity. [provided by RefSeq, Jul 2008]
- ENST00000326010
- ENSP00000324343
- ENSG00000100024
- BUP1
- BUP1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.81 | ||
kinase perturbation | 0.66 | ||
transcription factor | 0.63 | ||
cell line | 0.57 | ||
tissue sample | 0.53 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 55.63 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 87 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 55.63 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 87 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | beta-ureidopropionase 1 | VGNC:10415 | 747532 | |||||
Macaque | beta-ureidopropionase 1 | 707752 | ||||||
Mouse | MGI:2143535 | 103149 | ||||||
Dog | beta-ureidopropionase 1 | VGNC:48149 | 486398 | |||||
Horse | beta-ureidopropionase 1 | VGNC:24803 | 100053177 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | beta-ureidopropionase 1 | |||||
Macaque | beta-ureidopropionase 1 | |||||
Mouse | ||||||
Dog | beta-ureidopropionase 1 | |||||
Horse | beta-ureidopropionase 1 | |||||
Pathways (26)
Reactome (4)
KEGG (5)
PathwayCommons (4)
UniProt (1)
WikiPathways (12)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of nucleotides | ||||
Reactome | Nucleobase catabolism | ||||
Reactome | Pyrimidine catabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of nucleotides | ||||
Nucleobase catabolism | ||||
Pyrimidine catabolism | ||||
Gene Ontology Terms (7)
Functions (2)
Components (2)
Processes (3)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (68)
1 – 10 of 68
DPYS
Family: Enzyme
Novelty: 0.01272377
Score: 0.989
Data Source: STRINGDB
AGXT2
Family: Enzyme
Novelty: 0.02018289
Score: 0.985
Data Source: STRINGDB
DPYD
Family: Enzyme
Novelty: 0.00207216
Score: 0.982
Data Source: STRINGDB
ABAT
Family: Enzyme
Novelty: 0.0078359
Score: 0.927
Data Source: STRINGDB
ALDH9A1
Family: Enzyme
Novelty: 0.01688006
Score: 0.925
Data Source: STRINGDB
CNDP2
Family: Enzyme
Novelty: 0.00157228
Score: 0.917
Data Source: STRINGDB
GAD2
Family: Enzyme
Novelty: 0.00058427
Score: 0.917
Data Source: STRINGDB
CNDP1
Family: Enzyme
Novelty: 0.0102642
Score: 0.917
Data Source: STRINGDB
ALDH1B1
Family: Enzyme
Novelty: 0.01755208
Score: 0.914
Data Source: STRINGDB
ALDH2
Family: Enzyme
Novelty: 0.00077122
Score: 0.914
Data Source: STRINGDB
Publication Statistics
PubMed Score 55.63
PubMed score by year
PubTator Score 34.45
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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