GRHPR
Glyoxylate reductase/hydroxypyruvate reductase
Protein Summary
Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate. This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. [provided by RefSeq, Jul 2008]
- ENST00000318158
- ENSP00000313432
- ENSG00000137106
- ENST00000494290
- ENSP00000432021
- GLXR
- PH2
- GLXR
- GLYD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.97 | ||
transcription factor perturbation | 0.94 | ||
molecular function | 0.88 | ||
disease perturbation | 0.87 | ||
transcription factor | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 99.58 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 266 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 99.58 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 266 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0