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Tbio
EXTL2
Exostosin-like 2

Protein Summary
Description
Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370113
  • ENSP00000359131
  • ENSG00000162694
  • ENST00000370114
  • ENSP00000359132

Symbol
  • EXTR2
  • EXTR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.77
tissue sample
0.66
cellular component
0.65
transcription factor
0.63
histone modification site profile
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.87   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.87   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (66)
1 – 10 of 66
CSGALNACT2
Tbio
Family:  Enzyme
Novelty:  0.0770692
p_int:  0.999503811
p_ni:  0.000496189
Score:  0.639
Data Source:  BioPlex,STRINGDB
AOC3
Tchem
Family:  Enzyme
Novelty:  0.00078739
p_int:  0.999303611
p_ni:  0.000672676
p_wrong:  0.000023714
Score:  0.189
Data Source:  BioPlex,STRINGDB
TSPAN1
Tbio
Novelty:  0.01547855
p_int:  0.998513293
p_ni:  0.001402554
p_wrong:  0.000084153
Data Source:  BioPlex
SLC39A5
Tbio
Family:  Transporter
Novelty:  0.05205571
p_int:  0.997524514
p_ni:  0.002475465
p_wrong:  2e-8
Data Source:  BioPlex
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
p_int:  0.997298879
p_ni:  0.002701117
p_wrong:  5e-9
Data Source:  BioPlex
CLEC2B
Tbio
Novelty:  0.06581244
p_int:  0.997082401
p_ni:  0.002916588
p_wrong:  0.000001011
Data Source:  BioPlex
SPPL2B
Tchem
Family:  Enzyme
Novelty:  0.0274774
p_int:  0.995475729
p_ni:  0.003897943
p_wrong:  0.000626328
Data Source:  BioPlex
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
p_int:  0.994007716
p_ni:  0.003139563
p_wrong:  0.002852721
Data Source:  BioPlex
KCNA10
Tclin
Family:  IC
Novelty:  0.05708808
p_int:  0.992766471
p_ni:  0.007196118
p_wrong:  0.00003741
Data Source:  BioPlex
CLU
Tbio
Novelty:  0.00054776
p_int:  0.978960026
p_ni:  0.021038339
p_wrong:  0.000001635
Data Source:  BioPlex
Pathways (7)
IRE1alpha activates chaperones (R-HSA-381070)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
IRE1alpha activates chaperones
Reactome
Metabolism of proteins
Reactome
Unfolded Protein Response (UPR)
Reactome
XBP1(S) activates chaperone genes
Name
Explore in Pharos
Explore in Source
IRE1alpha activates chaperones
Metabolism of proteins
Unfolded Protein Response (UPR)
XBP1(S) activates chaperone genes
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
4
0
1.1
83
lymphocyte percentage of leukocytes
1
1
1
12.9
neutrophil percentage of leukocytes
1
1
1
12.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
83
lymphocyte percentage of leukocytes
1
12.9
neutrophil percentage of leukocytes
1
12.3
Find similar targets by:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
exostosin like glycosyltransferase 2
VGNC:11316
457060
Macaque
exostosin like glycosyltransferase 2
712189
Mouse
MGI:1889574
58193
Rat
RGD:1307684
310803
Dog
exostosin like glycosyltransferase 2
VGNC:40534
479925
Species
Name
OMA
EggNOG
Inparanoid
Chimp
exostosin like glycosyltransferase 2
Macaque
exostosin like glycosyltransferase 2
Mouse
Rat
Dog
exostosin like glycosyltransferase 2
Publication Statistics
PubMed Score 20.87
PubMed score by year
PubTator Score 10.11
PubTator score by year