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Tbio
EIF3K
Eukaryotic translation initiation factor 3 subunit K

Protein Summary
Description
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repressi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248342
  • ENSP00000248342
  • ENSG00000178982
  • ENST00000545173
  • ENSP00000438145
  • ENST00000635417
  • ENSP00000489379
  • ENSG00000282986
  • ENST00000635567
  • ENSP00000489438

Symbol
  • EIF3S12
  • M9
  • ARG134
  • PLAC24
  • PTD001
  • EIF3S12
  • HSPC029
  • MSTP001
  • PLAC-24
  • PRO1474
  • EIF3-p28
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
0.98
co-expressed gene
0.89
histone modification site profile
0.88
kinase perturbation
0.84


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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.9   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.9   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
1
1
1
0.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
1
0.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 3 subunit K
VGNC:6623
456009
Macaque
eukaryotic translation initiation factor 3 subunit K
693536
Mouse
MGI:1921080
73830
Dog
eukaryotic translation initiation factor 3 subunit K
VGNC:40277
476468
Horse
eukaryotic translation initiation factor 3 subunit K
VGNC:17495
100064307
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 3 subunit K
Macaque
eukaryotic translation initiation factor 3 subunit K
Mouse
Dog
eukaryotic translation initiation factor 3 subunit K
Horse
eukaryotic translation initiation factor 3 subunit K
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UBQ5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Cap-dependent Translation Initiation
Reactome
Eukaryotic Translation Initiation
Reactome
Formation of a pool of free 40S subunits
Reactome
Formation of the ternary complex, and subsequently, the 43S complex
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Cap-dependent Translation Initiation
Eukaryotic Translation Initiation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Protein-Protein Interactions (222)
1 – 10 of 222
EIF3L
Tbio
Novelty: 0.11054104
p_int: 0.999958029
p_ni: 0.000041971
Score: 0.999
Data Source: BioPlex,STRINGDB
EIF3I
Tbio
Novelty: 0.04398155
p_int: 0.999564975
p_ni: 0.000435025
Score: 0.999
Data Source: BioPlex,STRINGDB
EIF3E
Tbio
Novelty: 0.02154456
p_int: 0.999436259
p_ni: 0.000563741
Score: 0.999
Data Source: BioPlex,STRINGDB
EIF3H
Tbio
Novelty: 0.02564681
p_int: 0.999431218
p_ni: 0.000568782
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
EIF3M
Tbio
Novelty: 0.0174915
p_int: 0.99893314
p_ni: 0.00106686
Score: 0.999
Data Source: BioPlex,STRINGDB
EIF3D
Tbio
Novelty: 0.0360717
p_int: 0.998782201
p_ni: 0.001217799
Score: 0.999
Data Source: BioPlex,STRINGDB
EIF3F
Tbio
Novelty: 0.0319772
p_int: 0.995038384
p_ni: 0.004961616
Score: 0.999
Data Source: BioPlex,STRINGDB
EIF3C
Tbio
Novelty: 0.02844331
Score: 0.999
Data Source: STRINGDB
EIF3A
Tbio
Novelty: 0.00434615
Score: 0.999
Data Source: STRINGDB
EIF3G
Tbio
Novelty: 0.04737601
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  19.90

PubMed score by year
PubTator Score  257.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer