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Tbio
VPS29
Vacuolar protein sorting-associated protein 29

Protein Summary
Description
Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pI ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360579
  • ENSP00000353786
  • ENSG00000111237
  • ENST00000549578
  • ENSP00000447058

Symbol
  • DC7
  • DC15
  • PEP11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
interacting protein
0.87
kinase perturbation
0.81
small molecule perturbation
0.79
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.74   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.74   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (142)
1 – 10 of 142
VPS26A
Tbio
Novelty:  0.01804654
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
VPS26B
Tdark
Novelty:  0.25702869
p_int:  1
Score:  0.998
Data Source:  BioPlex,STRINGDB
TBC1D5
Tbio
Novelty:  0.11547525
p_int:  0.999999998
p_ni:  2e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
ANKRD27
Tbio
Novelty:  0.02843267
p_int:  0.999999985
p_ni:  1.5e-8
Score:  0.752
Data Source:  BioPlex,STRINGDB
C16orf62
Tdark
Novelty:  0.33867321
p_int:  0.999999616
p_ni:  3.84e-7
Score:  0.911
Data Source:  BioPlex,STRINGDB
COMMD10
Tbio
Novelty:  0.29057641
p_int:  0.999999141
p_ni:  8.59e-7
Score:  0.843
Data Source:  BioPlex,STRINGDB
VPS35
Tbio
Novelty:  0.00729892
p_int:  0.999997485
p_ni:  0.000002515
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
DSCR3
Tbio
Novelty:  0.05414856
p_int:  0.999994393
p_ni:  0.000005607
Score:  0.969
Data Source:  BioPlex,STRINGDB
COMMD9
Tdark
Novelty:  0.77223999
p_int:  0.999985296
p_ni:  0.000014704
Score:  0.85
Data Source:  BioPlex,STRINGDB
CCDC93
Tdark
Novelty:  0.19116791
p_int:  0.999982187
p_ni:  0.000017813
Score:  0.906
Data Source:  BioPlex,STRINGDB
Pathways (4)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
WNT ligand biogenesis and trafficking
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by WNT
WNT ligand biogenesis and trafficking
Gene Ontology Terms (14)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
1
2
71.3
body height
1
1
1
48.5
risk-taking behaviour
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
71.3
body height
1
48.5
risk-taking behaviour
1
21.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1928344
56433
Rat
RGD:1308332
288666
Dog
VPS29, retromer complex component
VGNC:48283
477477
Horse
VPS29, retromer complex component
VGNC:24921
100058295
Cow
VPS29, retromer complex component
VGNC:36816
513840
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
VPS29, retromer complex component
Horse
VPS29, retromer complex component
Cow
VPS29, retromer complex component
Publication Statistics
PubMed Score 72.74
PubMed score by year
PubTator Score 19.44
PubTator score by year