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Tbio
GULP1
PTB domain-containing engulfment adapter protein 1

Protein Summary
Description
May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6. The protein encoded by this gene is an adapter protein necessary for the engulfment of apoptotic cells by phagocytes. Several transcript variants, some protein coding and some thought not to be protein coding, have been found for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359135
  • ENSP00000352047
  • ENSG00000144366
  • ENST00000409580
  • ENSP00000386289
  • ENST00000409609
  • ENSP00000386867
  • ENST00000409637
  • ENSP00000386402
  • ENST00000409805
  • ENSP00000387171
  • ENST00000409830
  • ENSP00000386732
  • ENST00000409843
  • ENSP00000387144
  • ENST00000410051
  • ENSP00000387013

Symbol
  • CED6
  • GULP
  • CED6
  • GULP
  • CED-6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
PubMedID
0.9
interacting protein
0.86
virus perturbation
0.76
small molecule perturbation
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.67   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.67   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
MLLT6
Tdark
Family:  Epigenetic
Novelty:  0.03728427
p_int:  0.999999666
p_ni:  3.34e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
AP2M1
Tbio
Novelty:  0.00769368
p_int:  0.999999285
p_ni:  7.15e-7
Score:  0.205
Data Source:  BioPlex,STRINGDB
CCDC102B
Tdark
Novelty:  0.28075569
p_int:  0.999994743
p_ni:  0.000005248
p_wrong:  9e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
ANGPTL3
Tclin
Novelty:  0.00595539
p_int:  0.999545931
p_ni:  0.000454017
p_wrong:  5.2e-8
Score:  0.252
Data Source:  BioPlex,STRINGDB
ANKRD36B
Tdark
Novelty:  2.44907149
p_int:  0.949160763
p_ni:  0.000788216
p_wrong:  0.050051021
Data Source:  BioPlex
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.98
Data Source:  STRINGDB
ARF6
Tbio
Family:  Enzyme
Novelty:  0.00278138
Score:  0.922
Data Source:  STRINGDB
ACAP1
Tbio
Novelty:  0.04481025
Score:  0.921
Data Source:  STRINGDB
MEGF10
Tbio
Novelty:  0.03039995
Score:  0.908
Data Source:  STRINGDB
ELMO3
Tbio
Novelty:  0.05985405
Score:  0.903
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
56.4
hemoglobin A1 measurement
1
1
1
30.2
mathematical ability
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
56.4
hemoglobin A1 measurement
1
30.2
mathematical ability
1
21.5
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GULP, engulfment adaptor PTB domain containing 1
VGNC:1955
459812
Macaque
GULP, engulfment adaptor PTB domain containing 1
708601
Mouse
MGI:1920407
70676
Rat
RGD:1306380
314543
Dog
GULP, engulfment adaptor PTB domain containing 1
VGNC:53097
478834
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GULP, engulfment adaptor PTB domain containing 1
Macaque
GULP, engulfment adaptor PTB domain containing 1
Mouse
Rat
Dog
GULP, engulfment adaptor PTB domain containing 1
Publication Statistics
PubMed Score 77.67
PubMed score by year
PubTator Score 38.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title