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Tbio
HEY2
Hairy/enhancer-of-split related with YRPW motif protein 2

Protein Summary
Description
Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368364
  • ENSP00000357348
  • ENSG00000135547

Symbol
  • BHLHB32
  • CHF1
  • GRL
  • HERP
  • HERP1
  • HRT2
  • GRL
  • CHF1
  • HRT2
  • HERP1
  • HESR2
  • bHLHb32
  • GRIDLOCK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
gene perturbation
0.91
molecular function
0.76
transcription factor binding site profile
0.7
PubMedID
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.98   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.98   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 70
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
1
1
0
7.3
86.1
Brugada syndrome
1
1
0
1.6
42.5
electrocardiography
1
1
9
3.1
TPE interval measurement
1
1
1
2.2
body height
1
1
1
0.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
0
7.3
86.1
Brugada syndrome
0
1.6
42.5
electrocardiography
9
3.1
TPE interval measurement
1
2.2
body height
1
0.4
Pathways (54)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (R-HSA-2894862)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Disease
Diseases of signal transduction
Gene expression (Transcription)
Gene Ontology Terms (74)
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (97)
1 – 10 of 97
HEY1
Tbio
Family: TF
Novelty: 0.0042366
p_int: 1
Score: 0.971
Data Source: BioPlex,STRINGDB
ARL10
Tdark
Family: Enzyme
Novelty: 1.16329406
p_int: 0.985343926
p_ni: 0.014656074
Score: 0.243
Data Source: BioPlex,STRINGDB
CHMP1A
Tbio
Novelty: 0.03969333
p_int: 0.933350203
p_ni: 0.066222519
p_wrong: 0.000427278
Score: 0.694
Data Source: BioPlex,STRINGDB
IST1
Tbio
Novelty: 0.01780503
p_int: 0.915958092
p_ni: 0.000173996
p_wrong: 0.083867912
Score: 0.855
Data Source: BioPlex,STRINGDB
CARM1
Tchem
Family: Epigenetic
Novelty: 0.00623937
p_int: 0.773638002
p_ni: 0.226361998
Score: 0.218
Data Source: BioPlex,STRINGDB
NOTCH1
Tchem
Novelty: 0.00012547
Score: 0.993
Data Source: STRINGDB
RBPJ
Tbio
Family: TF
Novelty: 0.00168834
Score: 0.975
Data Source: STRINGDB
NOTCH3
Tchem
Novelty: 0.000953
Score: 0.971
Data Source: STRINGDB
NOTCH4
Tchem
Novelty: 0.00471643
Score: 0.969
Data Source: STRINGDB
GATA4
Tbio
Family: TF
Novelty: 0.00094282
Score: 0.966
Data Source: STRINGDB
Publication Statistics
PubMed Score  157.98

PubMed score by year
PubTator Score  201.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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