Tbio HEY2 Hairy/enhancer-of-split related with YRPW motif protein 2

Protein Summary

Description

Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UBP5

Gene Name

• HEY2

Ensembl ID

• ENST00000368364
• ENSP00000357348
• ENSG00000135547

Symbol

• BHLHB32
• CHF1
• GRL
• HERP
• HERP1
• HRT2
• GRL
• CHF1
• HRT2
• HERP1
• HESR2
• bHLHb32
• GRIDLOCK

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
gene perturbation	0.91
molecular function	0.76
transcription factor binding site profile	0.7
PubMedID	0.68

Protein Classes

PANTHER Classes

Protein / ... / Basic Helix-loop-helix Transcription Factor / Hairy/enhancer-of-split Related With Yrpw Motif Protein 2

DTO Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Hairy/enhancer-of-split Related With Yrpw Motif Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 180.33   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 208   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 180.33   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 70

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0