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Tbio
DKK3
Dickkopf-related protein 3

Protein Summary
Description
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326932
  • ENSP00000314910
  • ENSG00000050165
  • ENST00000396505
  • ENSP00000379762

Symbol
  • REIC
  • RIG
  • REIC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
PubMedID
0.9
kinase perturbation
0.81
biological term
0.75
small molecule perturbation
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 262.58   (req: < 5)
Gene RIFs: 109   (req: <= 3)
Antibodies: 561   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 262.58   (req: >= 5)
Gene RIFs: 109   (req: > 3)
Antibodies: 561   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (126)
UBA52
Tbio
Novelty:  0.01637744
p_int:  0.999998283
p_ni:  0.000001479
p_wrong:  2.38e-7
Data Source:  BioPlex
MYO5B
Tbio
Novelty:  0.01302142
p_int:  0.999998107
p_ni:  0.000001893
Score:  0.17
Data Source:  BioPlex,STRINGDB
TNIP2
Tbio
Novelty:  0.03640252
p_int:  0.999990347
p_ni:  0.000009652
p_wrong:  1e-9
Data Source:  BioPlex
CEP131
Tbio
Novelty:  0.02562073
p_int:  0.999982831
p_ni:  0.000017168
Data Source:  BioPlex
ATAD3C
Tdark
Family:  Enzyme
Novelty:  0.33587655
p_int:  0.999960794
p_ni:  0.000039205
Score:  0.189
Data Source:  BioPlex,STRINGDB
MYO5A
Tbio
Novelty:  0.00373224
p_int:  0.999940628
p_ni:  0.00005937
p_wrong:  2e-9
Score:  0.164
Data Source:  BioPlex,STRINGDB
GOSR2
Tbio
Novelty:  0.02447711
p_int:  0.9999392
p_ni:  0.0000608
Data Source:  BioPlex
ASPM
Tbio
Novelty:  0.00599688
p_int:  0.999917283
p_ni:  0.000082717
Score:  0.166
Data Source:  BioPlex,STRINGDB
MYO5C
Tbio
Novelty:  0.05680943
p_int:  0.999848326
p_ni:  0.000151674
Score:  0.165
Data Source:  BioPlex,STRINGDB
ABCB10
Tbio
Family:  Transporter
Novelty:  0.00351852
p_int:  0.999222171
p_ni:  0.000777829
Score:  0.163
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: inoh
Xenopus axis formation Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram )
PathwayCommons: inoh
Canonical Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram )
PathwayCommons: inoh
Canonical Wnt signaling pathway ( Canonical Wnt signaling pathway Diagram )
PathwayCommons: inoh
Canonical Wnt signaling pathway ( Drosophila Wingless/Wnt signaling pathway Diagram )
PathwayCommons: inoh
Canonical Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram )
Name
Explore in Pharos
Explore in Source
Xenopus axis formation Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram )
Canonical Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram )
Canonical Wnt signaling pathway ( Canonical Wnt signaling pathway Diagram )
Canonical Wnt signaling pathway ( Drosophila Wingless/Wnt signaling pathway Diagram )
Canonical Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram )
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
1
1
86.2
cortical surface area measurement
1
1
0
9
68.6
BMI-adjusted waist circumference
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
86.2
cortical surface area measurement
0
9
68.6
BMI-adjusted waist circumference
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dickkopf WNT signaling pathway inhibitor 3
VGNC:3132
451030
Macaque
dickkopf WNT signaling pathway inhibitor 3
701549
Mouse
MGI:1354952
50781
Rat
RGD:621846
171548
Dog
dickkopf WNT signaling pathway inhibitor 3
VGNC:39971
476857
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dickkopf WNT signaling pathway inhibitor 3
Macaque
dickkopf WNT signaling pathway inhibitor 3
Mouse
Rat
Dog
dickkopf WNT signaling pathway inhibitor 3
Publication Statistics
PubMed Score 262.58
PubMed score by year
PubTator Score 546.56
PubTator score by year
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Related Publications
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PMID
Year
Title