Tclin HDAC6 Histone deacetylase 6

Protein Summary

Description

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UBN7
• O94975
• Q6NT75
• Q7L3E5
• Q96CY0
• HD6

Gene Name

• HDAC6

Ensembl ID

• ENST00000334136
• ENSP00000334061
• ENSG00000094631
• ENST00000376619
• ENSP00000365804
• ENST00000426196
• ENSP00000402189
• ENST00000643374
• ENSP00000496046
• ENST00000644068
• ENSP00000496013

Symbol

• KIAA0901
• HD6
• JM21
• CPBHM
• PPP1R90

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	1
histone modification site profile	0.9
interacting protein	0.89
hub protein	0.88

Protein Classes

DTO Classes

Protein / Epigenetic Regulator / Eraser / Histone Deacetylase / Hdac Class Iib / Histone Deacetylase 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1138.75   (req: < 5)

Gene RIFs: 297   (req: <= 3)

Antibodies: 978   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1138.75   (req: >= 5)

Gene RIFs: 297   (req: > 3)

Antibodies: 978   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 68

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2725

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6