You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
HDAC6
Histone deacetylase 6

Protein Summary
Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggres ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334136
  • ENSP00000334061
  • ENSG00000094631
  • ENST00000376619
  • ENSP00000365804
  • ENST00000426196
  • ENSP00000402189
  • ENST00000643374
  • ENSP00000496046
  • ENST00000644068
  • ENSP00000496013

Symbol
  • KIAA0901
  • HD6
  • JM21
  • CPBHM
  • PPP1R90
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
histone modification site profile
0.9
interacting protein
0.89
hub protein
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1138.75   (req: < 5)
Gene RIFs: 214   (req: <= 3)
Antibodies: 978   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1138.75   (req: >= 5)
Gene RIFs: 214   (req: > 3)
Antibodies: 978   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 68
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2725
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6