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Tbio
CACNG4
Voltage-dependent calcium channel gamma-4 subunit

Protein Summary
Description
Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (PubMed:21127204). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization (PubMed:21172611). The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262138
  • ENSP00000262138
  • ENSG00000075461
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.8
molecular function
0.76
PubMedID
0.65
cell line
0.6
small molecule perturbation
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.42   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.42   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cup-to-disc ratio measurement
1
1
1
1.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cup-to-disc ratio measurement
1
1.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1859167
54377
Rat
RGD:628804
140725
Horse
calcium voltage-gated channel auxiliary subunit gamma 4
VGNC:15995
106780860
Cow
calcium voltage-gated channel auxiliary subunit gamma 4
VGNC:26689
519331
Opossum
calcium voltage-gated channel auxiliary subunit gamma 4
100024718
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
calcium voltage-gated channel auxiliary subunit gamma 4
Cow
calcium voltage-gated channel auxiliary subunit gamma 4
Opossum
calcium voltage-gated channel auxiliary subunit gamma 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UBN1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (28)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Developmental Biology
Reactome
Glutamate binding, activation of AMPA receptors and synaptic plasticity
Reactome
LGI-ADAM interactions
Reactome
Muscle contraction
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Developmental Biology
Glutamate binding, activation of AMPA receptors and synaptic plasticity
LGI-ADAM interactions
Muscle contraction
Gene Ontology Terms (26)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (109)
1 – 10 of 109
DPY19L3
Tbio
Family: Enzyme
Novelty: 0.35244121
p_int: 0.998055951
p_ni: 0.000013501
p_wrong: 0.001930548
Score: 0.214
Data Source: BioPlex,STRINGDB
MTX3
Tdark
Novelty: 0.06082176
p_int: 0.958789113
p_ni: 0.041210886
p_wrong: 2e-9
Score: 0.163
Data Source: BioPlex,STRINGDB
ARL10
Tdark
Family: Enzyme
Novelty: 1.16329406
p_int: 0.924408829
p_ni: 0.075591171
Score: 0.171
Data Source: BioPlex,STRINGDB
RMND1
Tbio
Novelty: 0.06181833
p_int: 0.90927038
p_ni: 0.090729534
p_wrong: 8.6e-8
Score: 0.179
Data Source: BioPlex,STRINGDB
MTX1
Tbio
Novelty: 0.02350764
p_int: 0.865095709
p_ni: 0.134904275
p_wrong: 1.7e-8
Score: 0.159
Data Source: BioPlex,STRINGDB
RSPRY1
Tdark
Novelty: 0.26883105
p_int: 0.817395206
p_ni: 0.182604449
p_wrong: 3.45e-7
Data Source: BioPlex
CACNB1
Tbio
Family: IC
Novelty: 0.06568749
Score: 0.962
Data Source: STRINGDB
CACNA1D
Tclin
Family: IC
Novelty: 0.00314752
Score: 0.956
Data Source: STRINGDB
CACNA2D1
Tclin
Family: IC
Novelty: 0.01744541
Score: 0.955
Data Source: STRINGDB
CACNA2D4
Tbio
Family: IC
Novelty: 0.02238343
Score: 0.942
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.42

PubMed score by year
PubTator Score  0.82

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer