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Tbio
OPTC
Opticin

Protein Summary
Description
Binds collagen fibrils. Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367222
  • ENSP00000356191
  • ENSG00000188770

Symbol
  • OPT
  • OPT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.65
cell line
0.53
transcription factor
0.48
protein domain
0.41
tissue
0.41


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.63   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.63   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip circumference
1
7
7
94.1
BMI-adjusted hip circumference
1
7
7
92.4
sex hormone-binding globulin measurement
2
2
2
63.2
triglyceride measurement
3
3
4
46
BMI-adjusted waist-hip ratio
2
1
2
9.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip circumference
7
94.1
BMI-adjusted hip circumference
7
92.4
sex hormone-binding globulin measurement
2
63.2
triglyceride measurement
4
46
BMI-adjusted waist-hip ratio
2
9.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
opticin
VGNC:11563
741181
Macaque
opticin
702570
Mouse
MGI:2151113
269120
Rat
RGD:1304916
304802
Dog
opticin
VGNC:44135
403591
Species
Name
OMA
EggNOG
Inparanoid
Chimp
opticin
Macaque
opticin
Mouse
Rat
Dog
opticin
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UBM4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Degradation of the extracellular matrix (R-HSA-1474228)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Degradation of the extracellular matrix
Extracellular matrix organization
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (36)
1 – 10 of 36
MMP13
Tchem
Family:  Enzyme
Novelty:  0.00057893
Score:  0.909
Data Source:  Reactome,STRINGDB
MMP7
Tchem
Family:  Enzyme
Novelty:  0.00080093
Score:  0.904
Data Source:  Reactome,STRINGDB
MMP2
Tchem
Family:  Enzyme
Novelty:  0.00012762
Score:  0.903
Data Source:  Reactome,STRINGDB
ALG5
Tbio
Family:  Enzyme
Novelty:  0.04358658
Score:  0.688
Data Source:  STRINGDB
ADGRL2
Tbio
Family:  GPCR
Novelty:  0.00985539
Score:  0.685
Data Source:  STRINGDB
ADGRL1
Tbio
Family:  GPCR
Novelty:  0.00957739
Score:  0.685
Data Source:  STRINGDB
ADGRL3
Tbio
Family:  GPCR
Novelty:  0.00268343
Score:  0.685
Data Source:  STRINGDB
NYX
Tbio
Novelty:  0.0100148
Score:  0.595
Data Source:  STRINGDB
MYOC
Tchem
Novelty:  0.00138004
Score:  0.569
Data Source:  STRINGDB
RBP3
Tbio
Family:  Enzyme
Novelty:  0.00204835
Score:  0.516
Data Source:  STRINGDB
Publication Statistics
PubMed Score  43.63

PubMed score by year
PubTator Score  40.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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