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Tbio
PEMT
Phosphatidylethanolamine N-methyltransferase

Protein Summary
Description
Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC). Phosphatidylcholine (PC) is the most abundant mammalian phospholipid. This gene encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. Another distinct synthetic pathway in nucleated cells converts intracellular choline to phosphatidylcholine by a three-step process. The protein isoforms encoded by this gene localize to the endoplasmic reticulum and mitochondria-associated membranes. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255389
  • ENSP00000255389
  • ENSG00000133027
  • ENST00000395781
  • ENSP00000379127
  • ENST00000395782
  • ENSP00000379128
  • ENST00000395783
  • ENSP00000379129

Symbol
  • PEMPT
  • PNMT
  • PLMT
  • PNMT
  • PEAMT
  • PEMPT
  • PEMT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.94
histone modification site profile
0.81
transcription factor
0.74
transcription factor binding site profile
0.73
cellular component
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.79   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.79   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (14)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PC
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PC
Gene Ontology Terms (22)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (107)
1 – 10 of 107
PISD
Tbio
Family: Enzyme
Novelty: 0.00936733
Score: 0.986
Data Source: STRINGDB
MBOAT2
Tbio
Family: Enzyme
Novelty: 0.03587281
Score: 0.961
Data Source: STRINGDB
PTDSS1
Tbio
Family: Enzyme
Novelty: 0.01029925
Score: 0.959
Data Source: STRINGDB
CEPT1
Tbio
Family: Enzyme
Novelty: 0.02109745
Score: 0.957
Data Source: STRINGDB
CHPT1
Tbio
Family: Enzyme
Novelty: 0.03546698
Score: 0.952
Data Source: STRINGDB
PTDSS2
Tbio
Family: Enzyme
Novelty: 0.12765957
Score: 0.948
Data Source: STRINGDB
MBOAT1
Tdark
Family: Enzyme
Novelty: 0.09090304
Score: 0.946
Data Source: STRINGDB
LPCAT3
Tbio
Family: Enzyme
Novelty: 0.00564842
Score: 0.945
Data Source: STRINGDB
SELENOI
Tbio
Family: Enzyme
Novelty: 0.00887397
Score: 0.944
Data Source: STRINGDB
CHDH
Tbio
Family: Enzyme
Novelty: 0.03655237
Score: 0.942
Data Source: STRINGDB
Publication Statistics
PubMed Score  106.79

PubMed score by year
PubTator Score  79.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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