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Tchem
P2RX2
P2X purinoceptor 2

Protein Summary
Description
Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle. The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343948
  • ENSP00000343339
  • ENSG00000187848
  • ENST00000348800
  • ENSP00000345095
  • ENST00000350048
  • ENSP00000343904
  • ENST00000351222
  • ENSP00000344502
  • ENST00000352418
  • ENSP00000341419
  • ENST00000389110
  • ENSP00000373762
  • ENST00000449132
  • ENSP00000405531
  • ENST00000643471
  • ENSP00000494644

Symbol
  • P2X2
  • P2X2
  • DFNA41
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
cellular component
0.94
biological process
0.84
kinase perturbation
0.84
tissue
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 419.33   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 311   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 419.33   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 311   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (84)
KIAA1586
Tdark
Novelty:  2.30999532
p_int:  0.999676872
p_ni:  0.000322982
p_wrong:  1.46e-7
Score:  0.187
Data Source:  BioPlex,STRINGDB
EIF2AK3
Tchem
Family:  Kinase
Novelty:  0.00044559
p_int:  0.99718514
p_ni:  0.00281486
Data Source:  BioPlex
CANX
Tbio
Novelty:  0.00087002
p_int:  0.988062811
p_ni:  0.011937189
Data Source:  BioPlex
C1QL1
Tdark
Novelty:  0.11689088
p_int:  0.982796139
p_ni:  0.016558375
p_wrong:  0.000645486
Data Source:  BioPlex
EVI5L
Tbio
Novelty:  0.70769557
p_int:  0.982676106
p_ni:  0.01616645
p_wrong:  0.001157444
Data Source:  BioPlex
D2HGDH
Tbio
Family:  Enzyme
Novelty:  0.04618268
p_int:  0.975345623
p_ni:  0.011680333
p_wrong:  0.012974044
Data Source:  BioPlex
STARD3
Tbio
Novelty:  0.01540936
p_int:  0.970308203
p_ni:  0.029691608
p_wrong:  1.89e-7
Data Source:  BioPlex
GXYLT1
Tdark
Family:  Enzyme
Novelty:  0.39064064
p_int:  0.965490806
p_ni:  0.033924994
p_wrong:  0.0005842
Score:  0.556
Data Source:  BioPlex,STRINGDB
FKBP7
Tbio
Family:  Enzyme
Novelty:  0.00572565
p_int:  0.958379469
p_ni:  0.041620142
p_wrong:  3.89e-7
Score:  0.173
Data Source:  BioPlex,STRINGDB
HS2ST1
Tbio
Family:  Enzyme
Novelty:  0.04520207
p_int:  0.943058629
p_ni:  0.056941371
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Elevation of cytosolic Ca2+ levels (R-HSA-139853)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Elevation of cytosolic Ca2+ levels
Reactome
Hemostasis
Reactome
Platelet calcium homeostasis
Reactome
Platelet homeostasis
Name
Explore in Pharos
Explore in Source
Elevation of cytosolic Ca2+ levels
Hemostasis
Platelet calcium homeostasis
Platelet homeostasis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (33)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
BHF-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
2
2
76.7
hematocrit
2
2
2
73.4
erythrocyte count
1
1
1
59.9
reticulocyte measurement
1
1
1
52.7
mean corpuscular volume
1
1
1
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
76.7
hematocrit
2
73.4
erythrocyte count
1
59.9
reticulocyte measurement
1
52.7
mean corpuscular volume
1
48.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
purinergic receptor P2X 2
VGNC:13334
100615394
Macaque
purinergic receptor P2X 2
693390
Mouse
MGI:2665170
231602
Rat
RGD:620251
114115
Dog
purinergic receptor P2X 2
VGNC:44208
448781
Species
Name
OMA
EggNOG
Inparanoid
Chimp
purinergic receptor P2X 2
Macaque
purinergic receptor P2X 2
Mouse
Rat
Dog
purinergic receptor P2X 2
Publication Statistics
PubMed Score 419.33
PubMed score by year
PubTator Score 161.50
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title