Tchem P2RX2 P2X purinoceptor 2

Protein Summary

Description

Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle. The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• Q9UBL9
• A6NGB4
• A6NH93
• A6NHC2
• A6NHU3
• A6NIG9
• Q6V9R6
• Q9NR37
• Q9NR38
• Q9UHD5
• Q9UHD6
• Q9UHD7
• Q9Y637
• Q9Y638
• P2X2

Gene Name

• P2RX2

Ensembl ID

• ENST00000343948
• ENSP00000343339
• ENSG00000187848
• ENST00000348800
• ENSP00000345095
• ENST00000350048
• ENSP00000343904
• ENST00000351222
• ENSP00000344502
• ENST00000352418
• ENSP00000341419
• ENST00000389110
• ENSP00000373762
• ENST00000449132
• ENSP00000405531
• ENST00000643471
• ENSP00000494644

Symbol

• P2X2
• P2X2
• DFNA41

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
cellular component	0.94
biological process	0.84
kinase perturbation	0.84
tissue	0.68

Protein Classes

DTO Classes

Protein / Ion Channel / Atp-gated P2x Receptor Cation Channel (P2x Receptor) Family / P2x Purinoceptor 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 419.33   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 311   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 419.33   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 311   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (2)

Explore Approved Drugs

1 – 2 of 2

adenosine triphosphate

P2RX2Tchem IC

AGONIST pEC50 : 6.3

suramin

P2RX2Tchem IC

pIC50 : 6.52

Active Ligands (5)

Explore Active Ligands

1 – 5 of 5

TNP-ATP

P2RX2Tchem IC

pKi : 7.31

Bz-ATP

P2RX2Tchem IC

pEC50 : 8.7

isoPPADS

P2RX2Tchem IC

pIC50 : 7.08

PSB-10211

P2RX2Tchem IC

-log(-) : 7

CHEMBL1672104

P2RX2Tchem IC

pIC50 : 6.16

Protein-Protein Interactions (84)

Explore Interacting Targets

1 – 10 of 84

• See Interactions on String-DB

KIAA1586

Tdark

Novelty:  2.30999532

p_int:  0.999676872

p_ni:  0.000322982

p_wrong:  1.46e-7

Score:  0.187

Data Source:  BioPlex,STRINGDB

EIF2AK3

Tchem

Family:  Kinase

Novelty:  0.00044559

p_int:  0.99718514

p_ni:  0.00281486

Data Source:  BioPlex

CANX

Tbio

Novelty:  0.00087002

p_int:  0.988062811

p_ni:  0.011937189

Data Source:  BioPlex

C1QL1

Tdark

Novelty:  0.11689088

p_int:  0.982796139

p_ni:  0.016558375

p_wrong:  0.000645486

Data Source:  BioPlex

EVI5L

Tbio

Novelty:  0.70769557

p_int:  0.982676106

p_ni:  0.01616645

p_wrong:  0.001157444

Data Source:  BioPlex

D2HGDH

Tbio

Family:  Enzyme

Novelty:  0.04618268

p_int:  0.975345623

p_ni:  0.011680333

p_wrong:  0.012974044

Data Source:  BioPlex

STARD3

Tbio

Novelty:  0.01540936

p_int:  0.970308203

p_ni:  0.029691608

p_wrong:  1.89e-7

Data Source:  BioPlex

GXYLT1

Tdark

Family:  Enzyme

Novelty:  0.39064064

p_int:  0.965490806

p_ni:  0.033924994

p_wrong:  0.0005842

Score:  0.556

Data Source:  BioPlex,STRINGDB

FKBP7

Tbio

Family:  Enzyme

Novelty:  0.00572565

p_int:  0.958379469

p_ni:  0.041620142

p_wrong:  3.89e-7

Score:  0.173

Data Source:  BioPlex,STRINGDB

HS2ST1

Tbio

Family:  Enzyme

Novelty:  0.04520207

p_int:  0.943058629

p_ni:  0.056941371

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (7)

Reactome (4)

KEGG (3)

Elevation of cytosolic Ca2+ levels (R-HSA-139853)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Elevation of cytosolic Ca2+ levels	16 targets	R-HSA-139853
Reactome	Hemostasis	666 targets	R-HSA-109582
Reactome	Platelet calcium homeostasis	28 targets	R-HSA-418360
Reactome	Platelet homeostasis	88 targets	R-HSA-418346

Name	Explore in Pharos	Explore in Source
Elevation of cytosolic Ca2+ levels	16 targets	R-HSA-139853
Hemostasis	666 targets	R-HSA-109582
Platelet calcium homeostasis	28 targets	R-HSA-418360
Platelet homeostasis	88 targets	R-HSA-418346

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (33)

Functions (6)

Components (8)

Processes (19)

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1 – 6 of 6

GO Term	Evidence	Assigned by
extracellularly ATP-gated cation channel activity	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	BHF-UCL
ATP-gated ion channel activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
purinergic nucleotide receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
ligand-gated ion channel activity	Traceable Author Statement (TAS)	ProtInc
ATP binding	Non-traceable Author Statement (NAS)	BHF-UCL

Disease Associations (null)

No disease associations found

GWAS Traits (12)

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5

1 – 5 of 12

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hemoglobin measurement	EFO_0004509	2	2	2		76.7
hematocrit	EFO_0004348	2	2	2		73.4
erythrocyte count	EFO_0004305	1	1	1		59.9
reticulocyte measurement	EFO_0010700	1	1	1		52.7
mean corpuscular volume	EFO_0004526	1	1	1		48.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 12

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hemoglobin measurement	EFO_0004509	2		76.7
hematocrit	EFO_0004348	2		73.4
erythrocyte count	EFO_0004305	1		59.9
reticulocyte measurement	EFO_0010700	1		52.7
mean corpuscular volume	EFO_0004526	1		48.5

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell membrane
Complete proteome
Deafness
Disease mutation
Disulfide bond
Glycoprotein
Hearing
Ion channel
Ion transport

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
atrial fibrillation
body height
erythrocyte count
hematocrit
hemoglobin measurement
low density lipoprotein cholesterol measurement
mathematical ability
mean corpuscular volume
mean reticulocyte volume

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
respiratory system phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	purinergic receptor P2X 2	VGNC:13334	100615394
Macaque	purinergic receptor P2X 2		693390
Mouse	purinergic receptor P2X, ligand-gated ion channel, 2	MGI:2665170	231602
Rat	purinergic receptor P2X 2	RGD:620251	114115
Dog	purinergic receptor P2X 2	VGNC:44208	448781

Species	Name	OMA	EggNOG	Inparanoid
Chimp	purinergic receptor P2X 2
Macaque	purinergic receptor P2X 2
Mouse	purinergic receptor P2X, ligand-gated ion channel, 2
Rat	purinergic receptor P2X 2
Dog	purinergic receptor P2X 2

Publication Statistics

PubMed Score 419.33

PubMed score by year

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PubTator Score 161.50

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Patents

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Related Publications

Text Mined References (41)

GeneRif Annotations (28)

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PMID	Year	Title