Tchem P2RX2 P2X purinoceptor 2

Protein Summary

Description

Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle. The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• Q9UBL9
• A6NGB4
• A6NH93
• A6NHC2
• A6NHU3
• A6NIG9
• Q6V9R6
• Q9NR37
• Q9NR38
• Q9UHD5
• Q9UHD6
• Q9UHD7
• Q9Y637
• Q9Y638
• P2X2

Gene Name

• P2RX2

Ensembl ID

• ENST00000343948
• ENSP00000343339
• ENSG00000187848
• ENST00000348800
• ENSP00000345095
• ENST00000350048
• ENSP00000343904
• ENST00000351222
• ENSP00000344502
• ENST00000352418
• ENSP00000341419
• ENST00000389110
• ENSP00000373762
• ENST00000449132
• ENSP00000405531
• ENST00000643471
• ENSP00000494644

Symbol

• P2X2
• P2X2
• DFNA41

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
cellular component	0.94
biological process	0.84
kinase perturbation	0.84
tissue	0.68

Protein Classes

DTO Classes

Protein / Ion Channel / Atp-gated P2x Receptor Cation Channel (P2x Receptor) Family / P2x Purinoceptor 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 438.23   (req: < 5)

Gene RIFs: 36   (req: <= 3)

Antibodies: 311   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 438.23   (req: >= 5)

Gene RIFs: 36   (req: > 3)

Antibodies: 311   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2