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Tbio
ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

Protein Summary
Description
Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343823
  • ENSP00000340896
  • ENSG00000129691
  • ENST00000428278
  • ENSP00000395310
  • ENST00000521652
  • ENSP00000430259

Symbol
  • ASH2L1
  • ASH2
  • Bre2
  • ASH2L1
  • ASH2L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
molecular function
0.84
histone modification site profile
0.83
biological process
0.79
hub protein
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.94   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 365   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.94   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 365   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
2
2
90.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
90.5
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ASH2 like, histone lysine methyltransferase complex subunit
VGNC:10321
464115
Macaque
ASH2 like histone lysine methyltransferase complex subunit
699382
Mouse
MGI:1344416
23808
Rat
RGD:1305632
290829
Dog
ASH2 like, histone lysine methyltransferase complex subunit
VGNC:50623
475589
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ASH2 like, histone lysine methyltransferase complex subunit
Macaque
ASH2 like histone lysine methyltransferase complex subunit
Mouse
Rat
Dog
ASH2 like, histone lysine methyltransferase complex subunit
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UBL3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Deactivation of the beta-catenin transactivating complex
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Chromatin modifying enzymes
Chromatin organization
Deactivation of the beta-catenin transactivating complex
Gene Ontology Terms (22)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (255)
1 – 10 of 255
WDR5
Tchem
Novelty: 0.0059945
p_int: 0.997907587
p_ni: 0.002092413
Score: 0.999
Data Source: BioPlex,STRINGDB
CXXC1
Tbio
Family: Epigenetic
Novelty: 0.01019251
p_int: 0.997256967
p_ni: 0.002743033
Score: 0.995
Data Source: BioPlex,STRINGDB
HCFC2
Tbio
Novelty: 0.12260416
p_int: 0.995612611
p_ni: 0.004387389
Score: 0.898
Data Source: BioPlex,STRINGDB
CSNK2B
Tbio
Family: Kinase
Novelty: 0.00152367
p_int: 0.961811722
p_ni: 0.038188278
Data Source: BioPlex
CCDC69
Tdark
Novelty: 0.37983713
p_int: 0.926165384
p_ni: 0.073834616
Data Source: BioPlex
C21orf58
Tdark
Novelty: 1.16236162
p_int: 0.910160761
p_ni: 0.089839239
Data Source: BioPlex
MICU2
Tbio
Novelty: 0.04146208
p_int: 0.780794313
p_ni: 0.219205687
Score: 0.295
Data Source: BioPlex,STRINGDB
ANKRD9
Tdark
Novelty: 0.43181793
p_int: 0.773168725
p_ni: 0.226831275
Data Source: BioPlex
EPB41L5
Tbio
Novelty: 0.0391959
p_int: 0.755882219
p_ni: 0.244117781
Score: 0.311
Data Source: BioPlex,STRINGDB
RBBP5
Tbio
Novelty: 0.02221059
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  57.94

PubMed score by year
PubTator Score  53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer