ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2
Protein Summary
Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.
- ENST00000343823
- ENSP00000340896
- ENSG00000129691
- ENST00000428278
- ENSP00000395310
- ENST00000521652
- ENSP00000430259
- ASH2L1
- ASH2
- Bre2
- ASH2L1
- ASH2L2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.99 | ||
molecular function | 0.84 | ||
histone modification site profile | 0.83 | ||
biological process | 0.79 | ||
hub protein | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 67 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 365 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 67 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 365 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0