Tbio ARPP21 cAMP-regulated phosphoprotein 21

Protein Summary

Description

Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons. This gene encodes a cAMP-regulated phosphoprotein. The encoded protein is enriched in the caudate nucleus and cerebellar cortex. A similar protein in mouse may be involved in regulating the effects of dopamine in the basal ganglia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

Uniprot Accession IDs

• Q9UBL0
• B4DG96
• Q49AK3
• Q49AS6
• Q4G0V4
• Q6NYC3
• Q86V31
• Q9UF93
• ARPP-21

Gene Name

• ARPP21

Ensembl ID

• ENST00000187397
• ENSP00000187397
• ENSG00000172995
• ENST00000396481
• ENSP00000379741
• ENST00000396482
• ENSP00000379742
• ENST00000412048
• ENSP00000390151
• ENST00000417925
• ENSP00000412326
• ENST00000427542
• ENSP00000401602
• ENST00000428373
• ENSP00000412411
• ENST00000432682
• ENSP00000389754
• ENST00000436702
• ENSP00000397720
• ENST00000438071
• ENSP00000410171
• ENST00000441454
• ENSP00000406964
• ENST00000444190
• ENSP00000405276
• ENST00000474696
• ENSP00000417838

Symbol

• TARPP
• RCS
• TARPP
• R3HDM3
• ARPP-21

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.75
cell type or tissue	0.74
transcription factor perturbation	0.68
virus perturbation	0.68
microRNA	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 507   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 147   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 507   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0