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Tbio
UXT
Protein UXT

Protein Summary
Description
Involved in gene transcription regulation (PubMed:28106301, PubMed:21730289). Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription (PubMed:11854421, PubMed:21730289). Together with URI1, associates with chromatin to the NKX3-1 promoter region (PubMed:21730289). Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm (PubMed:28106301). May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity (PubMed:17620405, PubMed:21307340). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:17554592). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (P ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333119
  • ENSP00000327797
  • ENSG00000126756
  • ENST00000335890
  • ENSP00000337393

Symbol
  • STAP1
  • ART-27
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
histone modification site profile
0.85
biological process
0.71
molecular function
0.7
cellular component
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.23   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 218   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.23   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 218   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (80)
PIH1D1
Tbio
Novelty:  0.10737369
p_int:  0.999999712
p_ni:  2.88e-7
Score:  0.894
Data Source:  BioPlex,STRINGDB
URI1
Tbio
Family:  Enzyme
Novelty:  0.04265162
p_int:  0.999923991
p_ni:  0.000076009
Score:  0.965
Data Source:  BioPlex,STRINGDB
POLR3A
Tbio
Family:  Enzyme
Novelty:  0.01508849
p_int:  0.999857221
p_ni:  0.000142779
Score:  0.832
Data Source:  BioPlex,STRINGDB
PDRG1
Tbio
Novelty:  0.09389276
p_int:  0.999790763
p_ni:  0.000209233
p_wrong:  4e-9
Score:  0.929
Data Source:  BioPlex,STRINGDB
POLR3D
Tbio
Family:  Enzyme
Novelty:  0.02616321
p_int:  0.999763478
p_ni:  0.000236522
Score:  0.74
Data Source:  BioPlex,STRINGDB
PFDN2
Tbio
Novelty:  0.08537716
p_int:  0.999637261
p_ni:  0.000362739
Score:  0.912
Data Source:  BioPlex,STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
p_int:  0.99945645
p_ni:  0.00054355
Score:  0.705
Data Source:  BioPlex,STRINGDB
RPAP2
Tbio
Family:  Enzyme
Novelty:  0.03383659
p_int:  0.999304769
p_ni:  0.000695231
Score:  0.699
Data Source:  BioPlex,STRINGDB
POLR3E
Tbio
Family:  Enzyme
Novelty:  0.06500715
p_int:  0.999072822
p_ni:  0.000927178
Score:  0.741
Data Source:  BioPlex,STRINGDB
RPAP3
Tbio
Family:  Enzyme
Novelty:  0.02003375
p_int:  0.995458839
p_ni:  0.004541162
Score:  0.925
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Transcriptional Regulation by E2F6
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Transcriptional Regulation by E2F6
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitously expressed prefoldin like chaperone
VGNC:1181
465609
Macaque
ubiquitously expressed prefoldin like chaperone
712682
Mouse
MGI:1277988
22294
Rat
RGD:1359326
299313
Dog
ubiquitously expressed prefoldin like chaperone
VGNC:48221
480900
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitously expressed prefoldin like chaperone
Macaque
ubiquitously expressed prefoldin like chaperone
Mouse
Rat
Dog
ubiquitously expressed prefoldin like chaperone
Publication Statistics
PubMed Score 41.23
PubMed score by year
PubTator Score 20.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title