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Tbio
RABL2A
Rab-like protein 2A

Protein Summary
Description
Plays an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail. This gene is a member of the RAB gene family which belongs to the RAS GTPase superfamily. The proteins in the family of RAS-related signaling molecules are small GTP-binding proteins that play important roles in the regulation of exocytotic and endocytotic pathways. This gene maps to the site of an ancestral telomere fusion event and may be a subtelomeric gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393165
  • ENSP00000376870
  • ENSG00000144134
  • ENST00000393166
  • ENSP00000376871
  • ENST00000393167
  • ENSP00000376872
  • ENST00000409875
  • ENSP00000387229
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
histone modification site profile
0.83
interacting protein
0.71
tissue sample
0.55
transcription factor perturbation
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.5   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.5   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Genes related to primary cilium development (based on CRISPR)
Name
Explore in Pharos
Explore in Source
Genes related to primary cilium development (based on CRISPR)
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (54)
1 – 10 of 54
CCDC34
Tbio
Novelty: 0.43478261
p_int: 0.999999821
p_ni: 1.78e-7
p_wrong: 1e-9
Score: 0.519
Data Source: BioPlex,STRINGDB
RPP25
Tbio
Family: Enzyme
Novelty: 0.08571429
p_int: 0.999937687
p_ni: 0.000062313
Score: 0.175
Data Source: BioPlex,STRINGDB
CEP19
Tbio
Novelty: 0.27833002
p_int: 0.99945384
p_ni: 0.000139531
p_wrong: 0.000406628
Score: 0.638
Data Source: BioPlex,STRINGDB
FIGNL1
Tbio
Family: Enzyme
Novelty: 0.12790427
p_int: 0.993829437
p_ni: 0.002834408
p_wrong: 0.003336155
Score: 0.213
Data Source: BioPlex,STRINGDB
FHIT
Tchem
Family: Enzyme
Novelty: 0.00132958
p_int: 0.911219662
p_ni: 0.039078108
p_wrong: 0.04970223
Score: 0.318
Data Source: BioPlex,STRINGDB
ALMS1
Tbio
Novelty: 0.00695417
p_int: 0.897361466
p_ni: 0.102638534
Score: 0.193
Data Source: BioPlex,STRINGDB
SEC23IP
Tbio
Novelty: 0.13247818
p_int: 0.857524404
p_ni: 0.14231964
p_wrong: 0.000155956
Score: 0.205
Data Source: BioPlex,STRINGDB
MTO1
Tbio
Novelty: 0.00327053
p_int: 0.807644878
p_ni: 0.103158548
p_wrong: 0.089196574
Score: 0.185
Data Source: BioPlex,STRINGDB
BRCA2
Tbio
Novelty: 0.00031192
p_int: 0.776518255
p_ni: 0.223481745
Score: 0.171
Data Source: BioPlex,STRINGDB
APPL2
Tbio
Novelty: 0.14475271
Score: 0.917
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.50

PubMed score by year
PubTator Score  2.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer