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Tbio
HCST
Hematopoietic cell signal transducer

Protein Summary
Description
Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST rece ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246551
  • ENSP00000246551
  • ENSG00000126264
  • ENST00000437550
  • ENSP00000400516

Symbol
  • DAP10
  • KAP10
  • PIK3AP
  • DAP10
  • KAP10
  • PIK3AP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.81
tissue sample
0.69
virus perturbation
0.68
protein complex
0.66
phenotype
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.44   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.44   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.9
78.5
creatinine measurement
1
1
1
66.8
thrombomodulin measurement
1
1
1
64
glomerular filtration rate
1
1
1
62.8
vitamin D measurement
2
1
2
53.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.9
78.5
creatinine measurement
1
66.8
thrombomodulin measurement
1
64
glomerular filtration rate
1
62.8
vitamin D measurement
2
53.7
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hematopoietic cell signal transducer
VGNC:2340
748082
Macaque
hematopoietic cell signal transducer
574152
Mouse
MGI:1344360
23900
Rat
RGD:1359238
474146
Dog
hematopoietic cell signal transducer
VGNC:53722
612627
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hematopoietic cell signal transducer
Macaque
hematopoietic cell signal transducer
Mouse
Rat
Dog
hematopoietic cell signal transducer
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UBK5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (123)
1 – 10 of 123
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
Score:  0.983
Data Source:  STRINGDB
MICA
Tbio
Novelty:  0.03965901
Score:  0.966
Data Source:  STRINGDB
MICB
Tbio
Novelty:  0.00364639
Score:  0.965
Data Source:  STRINGDB
ULBP1
Tbio
Novelty:  0.01603533
Score:  0.962
Data Source:  STRINGDB
ULBP3
Tbio
Novelty:  0.0320239
Score:  0.962
Data Source:  STRINGDB
RAET1E
Tbio
Novelty:  0.01859274
Score:  0.951
Data Source:  STRINGDB
GRB2
Tchem
Novelty:  0.00091605
Score:  0.942
Data Source:  STRINGDB
KLRK1
Tbio
Novelty:  0.0009209
Score:  0.923
Data Source:  Reactome,STRINGDB
PIK3R1
Tchem
Family:  Kinase
Novelty:  0.00179772
Score:  0.87
Data Source:  STRINGDB
PLCG2
Tchem
Family:  Enzyme
Novelty:  0.00294726
Score:  0.847
Data Source:  STRINGDB
Publication Statistics
PubMed Score  51.44

PubMed score by year
PubTator Score  68.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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