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Tbio
PPARGC1A
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Protein Summary
Description
Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK. The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264867
  • ENSP00000264867
  • ENSG00000109819
  • ENST00000506055
  • ENSP00000423075
  • ENST00000513205
  • ENSP00000421632
  • ENST00000613098
  • ENSP00000481498

Symbol
  • LEM6
  • PGC1
  • PGC1A
  • PPARGC1
  • LEM6
  • PGC1
  • PGC1A
  • PGC-1v
  • PPARGC1
  • PGC-1alpha
  • PGC-1(alpha)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.96
chemical
0.92
gene perturbation
0.91
transcription factor perturbation
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3263.47   (req: < 5)
Gene RIFs: 484   (req: <= 3)
Antibodies: 292   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3263.47   (req: >= 5)
Gene RIFs: 484   (req: > 3)
Antibodies: 292   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 98
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
4
4
91.1
sex hormone-binding globulin measurement
5
3
5
88.6
hemoglobin measurement
2
3
3
87.3
glomerular filtration rate
4
4
3
5.5
83.4
self reported educational attainment
1
1
1
60.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
4
91.1
sex hormone-binding globulin measurement
5
88.6
hemoglobin measurement
3
87.3
glomerular filtration rate
3
5.5
83.4
self reported educational attainment
1
60.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PPARG coactivator 1 alpha
VGNC:12958
461140
Macaque
PPARG coactivator 1 alpha
715762
Mouse
MGI:1342774
19017
Rat
RGD:620925
83516
Dog
PPARG coactivator 1 alpha
VGNC:44837
479127
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PPARG coactivator 1 alpha
Macaque
PPARG coactivator 1 alpha
Mouse
Rat
Dog
PPARG coactivator 1 alpha
Protein Structure (14 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UBK2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (54)
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (R-HSA-2151209)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Reactome
Circadian Clock
Reactome
Developmental Biology
Reactome
FOXO-mediated transcription
Reactome
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Name
Explore in Pharos
Explore in Source
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Circadian Clock
Developmental Biology
FOXO-mediated transcription
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Gene Ontology Terms (108)
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (328)
1 – 10 of 328
ESRRA
Tchem
Family:  NR
Novelty:  0.003235
Score:  0.999
Data Source:  Reactome,STRINGDB
PPARG
Tclin
Family:  NR
Novelty:  0.00010033
Score:  0.999
Data Source:  STRINGDB
PPARA
Tclin
Family:  NR
Novelty:  0.00017403
Score:  0.994
Data Source:  STRINGDB
SIRT1
Tchem
Family:  Epigenetic
Novelty:  0.00022265
Score:  0.993
Data Source:  STRINGDB
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
Score:  0.983
Data Source:  STRINGDB
TWIST1
Tbio
Family:  TF
Novelty:  0.0013639
Score:  0.983
Data Source:  STRINGDB
NRF1
Tbio
Family:  TF
Novelty:  0.00543248
Score:  0.98
Data Source:  Reactome,STRINGDB
SIRT3
Tchem
Family:  Epigenetic
Novelty:  0.00101187
Score:  0.979
Data Source:  STRINGDB
TFAM
Tbio
Family:  TF
Novelty:  0.00131608
Score:  0.979
Data Source:  STRINGDB
SLC2A4
Tchem
Family:  Transporter
Novelty:  0.00033701
Score:  0.978
Data Source:  STRINGDB
Publication Statistics
PubMed Score  3263.47

PubMed score by year
PubTator Score  1283.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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