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Tbio
HECA
Headcase protein homolog

Protein Summary
Description
May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs. This gene encodes the homolog of the Drosophila headcase protein, a highly basic, cytoplasmic protein that regulates the re-entry of imaginal cells into the mitotic cycle during adult morphogenesis. In Drosophila, the encoded protein also inhibits terminal branching of neighboring cells during tracheal development. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367658
  • ENSP00000356630
  • ENSG00000112406

Symbol
  • HDC
  • HDC
  • HDCL
  • HHDC
  • dJ225E12.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
disease perturbation
0.83
transcription factor perturbation
0.74
virus perturbation
0.72
cell type or tissue
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.06   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.06   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (20)
UNK
Tbio
Novelty:  0.01101154
Score:  0.92
Data Source:  STRINGDB
SNX20
Tdark
Novelty:  0.28934317
Score:  0.804
Data Source:  STRINGDB
FUT6
Tchem
Family:  Enzyme
Novelty:  0.0123682
Score:  0.711
Data Source:  STRINGDB
UNKL
Tdark
Family:  Enzyme
Novelty:  1.37466055
Score:  0.689
Data Source:  STRINGDB
SELPLG
Tbio
Novelty:  0.0016359
Score:  0.669
Data Source:  STRINGDB
SELE
Tchem
Novelty:  0.00029494
Score:  0.668
Data Source:  STRINGDB
GLG1
Tbio
Novelty:  0.01332149
Score:  0.652
Data Source:  STRINGDB
GCNT1
Tbio
Family:  Enzyme
Novelty:  0.01487872
Score:  0.651
Data Source:  STRINGDB
FUT7
Tchem
Family:  Enzyme
Novelty:  0.01257357
Score:  0.641
Data Source:  STRINGDB
SELL
Tchem
Novelty:  0.00030025
Score:  0.613
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hdc homolog, cell cycle regulator
VGNC:2859
472138
Macaque
hdc homolog, cell cycle regulator
702628
Mouse
MGI:2685715
380629
Rat
RGD:1304818
308624
Dog
hdc homolog, cell cycle regulator
VGNC:41641
476223
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hdc homolog, cell cycle regulator
Macaque
hdc homolog, cell cycle regulator
Mouse
Rat
Dog
hdc homolog, cell cycle regulator
Publication Statistics
PubMed Score 107.06
PubMed score by year
PubTator Score 33.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title