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Tbio
GNG12
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370982
  • ENSP00000360021
  • ENSG00000172380
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
kinase perturbation
0.99
transcription factor perturbation
0.91
PubMedID
0.84
ligand (protein) perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.6   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 52   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.6   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 52   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
14.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
14.3
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
G protein subunit gamma 12
100424606
Mouse
MGI:1336171
14701
Rat
RGD:621516
114120
Dog
G protein subunit gamma 12
VGNC:41318
100686332
Horse
G protein subunit gamma 12
VGNC:18429
100630574
Species
Name
OMA
EggNOG
Inparanoid
Macaque
G protein subunit gamma 12
Mouse
Rat
Dog
G protein subunit gamma 12
Horse
G protein subunit gamma 12
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UBI6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (108)
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 59
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 1
Reactome
ADP signalling through P2Y purinoceptor 12
Reactome
Activation of G protein gated Potassium channels
Reactome
Activation of GABAB receptors
Reactome
Activation of kainate receptors upon glutamate binding
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 12
Activation of G protein gated Potassium channels
Activation of GABAB receptors
Activation of kainate receptors upon glutamate binding
Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (563)
1 – 10 of 563
GNB4
Tbio
Novelty: 0.08250797
Score: 0.999
Data Source: STRINGDB
GNB2
Tbio
Novelty: 0.08682553
Score: 0.999
Data Source: STRINGDB
GNB3
Tbio
Novelty: 0.0037117
Score: 0.999
Data Source: STRINGDB
GNB1
Tbio
Novelty: 0.02477955
Score: 0.999
Data Source: STRINGDB
GNB5
Tbio
Novelty: 0.0067714
Score: 0.967
Data Source: STRINGDB
GNA13
Tbio
Novelty: 0.04149138
Score: 0.964
Data Source: STRINGDB
GNG13
Tbio
Novelty: 0.13011919
Score: 0.962
Data Source: STRINGDB
GNA11
Tbio
Novelty: 0.00128664
Score: 0.961
Data Source: STRINGDB
GNA12
Tbio
Novelty: 0.06310884
Score: 0.959
Data Source: STRINGDB
GNAO1
Tbio
Novelty: 0.00315097
Score: 0.958
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.60

PubMed score by year
PubTator Score  4.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer