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Tbio
STOML1
Stomatin-like protein 1

Protein Summary
Description
May play a role in cholesterol transfer to late endosomes (PubMed:19696025). May play a role in modulating membrane acid-sensing ion channels. Can specifically inhibit proton-gated current of ASIC1 isoform 1. Can increase inactivation speed of ASIC3. May be involved in regulation of proton sensing in dorsal root ganglions (By similarity). May play a role in protecting FBXW7 isoform 3 from degradation (PubMed:23082202).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316900
  • ENSP00000319323
  • ENSG00000067221
  • ENST00000316911
  • ENSP00000319384
  • ENST00000359750
  • ENSP00000352788
  • ENST00000541638
  • ENSP00000442478
  • ENST00000564777
  • ENSP00000456343

Symbol
  • SLP1
  • UNC24
  • SLP-1
  • STORP
  • hUNC-24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
transcription factor binding site profile
0.88
transcription factor perturbation
0.74
tissue sample
0.72
transcription factor
0.66


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.93   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.93   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
stomatin like 1
VGNC:6453
467819
Macaque
stomatin like 1
700510
Mouse
MGI:1916356
69106
Rat
RGD:1559463
300748
Dog
stomatin like 1
VGNC:54370
487640
Species
Name
OMA
EggNOG
Inparanoid
Chimp
stomatin like 1
Macaque
stomatin like 1
Mouse
Rat
Dog
stomatin like 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UBI4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (37)
1 – 10 of 37
IL13RA2
Tbio
Novelty: 0.03465642
p_int: 0.997483433
p_ni: 0.000077257
p_wrong: 0.00243931
Score: 0.189
Data Source: BioPlex,STRINGDB
SDR39U1
Tdark
Family: Enzyme
Novelty: 0.38626113
Score: 0.762
Data Source: STRINGDB
RNF17
Tbio
Family: Epigenetic
Novelty: 0.09240471
Score: 0.731
Data Source: STRINGDB
WDR73
Tbio
Novelty: 0.10253438
Score: 0.73
Data Source: STRINGDB
SCP2D1
Tdark
Novelty: 1.03749683
Score: 0.723
Data Source: STRINGDB
UNC119
Tchem
Novelty: 0.00396292
Score: 0.715
Data Source: STRINGDB
RBM34
Tdark
Novelty: 0.58131282
Score: 0.714
Data Source: STRINGDB
LOXL1
Tbio
Family: Enzyme
Novelty: 0.00479897
Score: 0.703
Data Source: STRINGDB
STXBP6
Tbio
Novelty: 0.13195671
Score: 0.692
Data Source: STRINGDB
NYNRIN
Tdark
Novelty: 0.12231563
Score: 0.684
Data Source: STRINGDB
Publication Statistics
PubMed Score  14.93

PubMed score by year
PubTator Score  6.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer