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Tbio
COMMD3
COMM domain-containing protein 3

Protein Summary
Description
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376836
  • ENSP00000366032
  • ENSG00000148444

Symbol
  • BUP
  • C10orf8
  • BUP
  • C10orf8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor binding site profile
0.86
histone modification site profile
0.84
disease perturbation
0.83
transcription factor
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.12   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.12   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate specific antigen measurement
1
1
1
12.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate specific antigen measurement
1
12.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
COMM domain containing 3
VGNC:1605
100609446
Mouse
MGI:88218
12238
Rat
RGD:735116
291339
Dog
COMM domain containing 3
VGNC:39494
477977
Horse
COMM domain containing 3
VGNC:16760
100055759
Species
Name
OMA
EggNOG
Inparanoid
Chimp
COMM domain containing 3
Mouse
Rat
Dog
COMM domain containing 3
Horse
COMM domain containing 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UBI1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Metabolism of proteins
Neddylation
Neutrophil degranulation
Gene Ontology Terms (5)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (207)
1 – 10 of 207
COMMD10
Tbio
Novelty:  0.29057641
p_int:  1
Score:  0.996
Data Source:  BioPlex,STRINGDB
COMMD2
Tdark
Novelty:  0.62195903
p_int:  1
Score:  0.996
Data Source:  BioPlex,STRINGDB
COMMD4
Tbio
Novelty:  0.20453574
p_int:  1
Score:  0.993
Data Source:  BioPlex,STRINGDB
COMMD8
Tdark
Novelty:  0.33240242
p_int:  1
Score:  0.993
Data Source:  BioPlex,STRINGDB
COMMD1
Tbio
Novelty:  0.01349432
p_int:  1
Score:  0.991
Data Source:  BioPlex,STRINGDB
CCDC22
Tbio
Novelty:  0.01400901
p_int:  1
Score:  0.991
Data Source:  BioPlex,STRINGDB
FAM45A
Tdark
Novelty:  0.94034891
p_int:  1
Score:  0.834
Data Source:  BioPlex,STRINGDB
COMMD6
Tbio
Novelty:  0.11854363
p_int:  0.999999998
p_ni:  2e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
COMMD5
Tbio
Novelty:  0.16163787
p_int:  0.999999952
p_ni:  4.8e-8
Score:  0.993
Data Source:  BioPlex,STRINGDB
CCDC93
Tdark
Novelty:  0.19116791
p_int:  0.99999981
p_ni:  1.9e-7
Score:  0.892
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  14.12

PubMed score by year
PubTator Score  25.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer