Tbio IL36RN Interleukin-36 receptor antagonist protein

Protein Summary

Description

Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UBH0
• A8K2I4
• Q56AT9
• Q7RTZ6
• IL-36Ra

Gene Name

• IL36RN

Ensembl ID

• ENST00000346807
• ENSP00000259212
• ENSG00000136695
• ENST00000393200
• ENSP00000376896

Symbol

• FIL1D
• IL1F5
• IL1HY1
• IL1L1
• IL1RP3
• FIL1
• FIL1D
• IL1F5
• IL1L1
• PSORP
• IL1HY1
• IL1RP3
• IL36RA
• IL-36Ra
• PSORS14
• FIL1(DELTA)

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.85
protein domain	0.73
tissue	0.64
virus perturbation	0.59
molecular function	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 198.79   (req: < 5)

Gene RIFs: 64   (req: <= 3)

Antibodies: 243   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 198.79   (req: >= 5)

Gene RIFs: 64   (req: > 3)

Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0