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Tbio
RBPJL
Recombining binding protein suppressor of hairless-like protein

Protein Classes
Protein Summary
Description
Putative transcription factor, which cooperates with EBNA2 to activate transcription. This gene encodes a member of the suppressor of hairless protein family. A similar protein in mouse is a transcription factor that binds to DNA sequences almost identical to that bound by the Notch receptor signaling pathway transcription factor recombining binding protein J. The mouse protein has been shown to activate transcription in concert with Epstein-Barr virus nuclear antigen-2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343694
  • ENSP00000341243
  • ENSG00000124232
  • ENST00000372743
  • ENSP00000361828

Symbol
  • RBPL
  • RBPSUHL
  • RBPL
  • SUHL
  • RBPSUHL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
molecular function
0.7
gene perturbation
0.6
biological process
0.52
cellular component
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.24   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.24   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (38)
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Th1 and Th2 cell differentiation
KEGG
Viral carcinogenesis
KEGG
Human papillomavirus infection
KEGG
Notch signaling pathway
KEGG
Epstein-Barr virus infection
Name
Explore in Pharos
Explore in Source
Th1 and Th2 cell differentiation
Viral carcinogenesis
Human papillomavirus infection
Notch signaling pathway
Epstein-Barr virus infection
Gene Ontology Terms (9)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (43)
1 – 10 of 43
NOTCH1
Tchem
Novelty: 0.00012547
Score: 0.912
Data Source: STRINGDB
NOTCH3
Tchem
Novelty: 0.000953
Score: 0.871
Data Source: STRINGDB
PTF1A
Tbio
Family: TF
Novelty: 0.00593299
Score: 0.868
Data Source: STRINGDB
NOTCH2
Tchem
Novelty: 0.00195617
Score: 0.866
Data Source: STRINGDB
NOTCH4
Tchem
Novelty: 0.00471643
Score: 0.865
Data Source: STRINGDB
CIR1
Tdark
Novelty: 0.31735301
Score: 0.865
Data Source: STRINGDB
CTBP2
Tchem
Novelty: 0.00538964
Score: 0.858
Data Source: STRINGDB
CTBP1
Tbio
Novelty: 0.00243818
Score: 0.858
Data Source: STRINGDB
MAML3
Tbio
Novelty: 0.05574812
Score: 0.853
Data Source: STRINGDB
NCOR2
Tchem
Family: TF
Novelty: 0.00066449
Score: 0.844
Data Source: STRINGDB
Publication Statistics
PubMed Score  21.24

PubMed score by year
PubTator Score  55.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer