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Tbio
MRC2
C-type mannose receptor 2

Protein Summary
Description
May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs). This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degrad ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303375
  • ENSP00000307513
  • ENSG00000011028

Symbol
  • CLEC13E
  • ENDO180
  • KIAA0709
  • UPARAP
  • CD280
  • UPARAP
  • CLEC13E
  • ENDO180
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
protein domain
0.92
PubMedID
0.86
transcription factor perturbation
0.84
transcription factor
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.79   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 235   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.79   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 235   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
54
mathematical ability
1
1
1
48.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
54
mathematical ability
1
48.6
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Cross-presentation of soluble exogenous antigens (endosomes)
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing-Cross presentation
Class I MHC mediated antigen processing & presentation
Cross-presentation of soluble exogenous antigens (endosomes)
Immune System
Gene Ontology Terms (9)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (33)
1 – 10 of 33
FAM19A4
Tbio
Novelty: 0.04305684
p_int: 0.999901678
p_ni: 0.000098322
Score: 0.236
Data Source: BioPlex,STRINGDB
LGALS8
Tchem
Novelty: 0.00623836
p_int: 0.999634828
p_ni: 0.000365172
Score: 0.252
Data Source: BioPlex,STRINGDB
LGALS3
Tchem
Novelty: 0.00032754
p_int: 0.998766244
p_ni: 0.001233754
p_wrong: 1e-9
Score: 0.408
Data Source: BioPlex,STRINGDB
FAM19A2
Tbio
Novelty: 0.28999346
p_int: 0.998495485
p_ni: 0.001504515
Data Source: BioPlex
LGALS9
Tchem
Novelty: 0.00381766
p_int: 0.998363022
p_ni: 0.001636978
Score: 0.297
Data Source: BioPlex,STRINGDB
NDP
Tbio
Novelty: 0.01020963
p_int: 0.97272045
p_ni: 0.027278993
p_wrong: 5.57e-7
Data Source: BioPlex
ST8SIA4
Tbio
Family: Enzyme
Novelty: 0.00338436
p_int: 0.942253317
p_ni: 0.057746682
Data Source: BioPlex
PATE1
Tbio
Novelty: 0.0705075
p_int: 0.919645483
p_ni: 0.080349314
p_wrong: 0.000005203
Data Source: BioPlex
C1QTNF9B
Tdark
Novelty: 0.7643008
p_int: 0.914995336
p_ni: 0.084994804
p_wrong: 0.00000986
Data Source: BioPlex
FAM19A3
Tdark
Novelty: 0.37183557
p_int: 0.895956798
p_ni: 0.104043202
Data Source: BioPlex
Publication Statistics
PubMed Score  109.79

PubMed score by year
PubTator Score  64.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer