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Tchem
PI4KB
Phosphatidylinositol 4-kinase beta

Protein Summary
Description
Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368872
  • ENSP00000357866
  • ENSG00000143393
  • ENST00000368873
  • ENSP00000357867
  • ENST00000368874
  • ENSP00000357868
  • ENST00000529142
  • ENSP00000433149

Symbol
  • PIK4CB
  • NPIK
  • PI4K92
  • PIK4CB
  • PI4KBETA
  • PI4K-BETA
  • PI4KIIIBETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
protein domain
0.85
transcription factor perturbation
0.84
disease perturbation
0.83
ligand (protein) perturbation
0.83


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.22   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.22   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 28
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
1
1
0
5.6
29.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
0
5.6
29.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
phosphatidylinositol 4-kinase beta
710104
Mouse
MGI:1334433
107650
Rat
RGD:621214
81747
Dog
phosphatidylinositol 4-kinase beta
VGNC:44517
483196
Horse
phosphatidylinositol 4-kinase beta
VGNC:21409
100055429
Species
Name
OMA
EggNOG
Inparanoid
Macaque
phosphatidylinositol 4-kinase beta
Mouse
Rat
Dog
phosphatidylinositol 4-kinase beta
Horse
phosphatidylinositol 4-kinase beta
Protein Structure (16 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UBF8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 16
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Reactome
Synthesis of PIPs at the Golgi membrane
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Synthesis of PIPs at the Golgi membrane
Gene Ontology Terms (16)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (156)
1 – 10 of 156
DNAJC10
Tbio
Novelty: 0.02258366
p_int: 0.999999566
p_ni: 4.32e-7
p_wrong: 2e-9
Score: 0.223
Data Source: BioPlex,STRINGDB
CASP1
Tchem
Family: Enzyme
Novelty: 0.00034643
p_int: 0.999999422
p_ni: 5.76e-7
p_wrong: 2e-9
Score: 0.3
Data Source: BioPlex,STRINGDB
RDM1
Tbio
Novelty: 0.09585781
p_int: 0.999998931
p_ni: 0.000001069
Score: 0.455
Data Source: BioPlex,STRINGDB
CDK7
Tchem
Family: Kinase
Novelty: 0.00322814
p_int: 0.99999293
p_ni: 0.00000707
Score: 0.215
Data Source: BioPlex,STRINGDB
KBTBD7
Tdark
Novelty: 0.4947466
p_int: 0.999970128
p_ni: 0.000029864
p_wrong: 8e-9
Data Source: BioPlex
PIP5K1A
Tbio
Family: Kinase
Novelty: 0.05039085
Score: 0.974
Data Source: STRINGDB
ARF1
Tchem
Family: Enzyme
Novelty: 0.00208554
Score: 0.971
Data Source: Reactome,STRINGDB
PIKFYVE
Tchem
Family: Kinase
Novelty: 0.00441336
Score: 0.97
Data Source: STRINGDB
SACM1L
Tbio
Family: Enzyme
Novelty: 0.00499867
Score: 0.969
Data Source: STRINGDB
PIP5K1C
Tchem
Family: Kinase
Novelty: 0.0323077
Score: 0.967
Data Source: STRINGDB
Publication Statistics
PubMed Score  119.22

PubMed score by year
PubTator Score  33.91

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer