PI4KB
Phosphatidylinositol 4-kinase beta
Protein Summary
Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity).
- ENST00000368872
- ENSP00000357866
- ENSG00000143393
- ENST00000368873
- ENSP00000357867
- ENST00000368874
- ENSP00000357868
- ENST00000529142
- ENSP00000433149
- PIK4CB
- NPIK
- PI4K92
- PIK4CB
- PI4KBETA
- PI4K-BETA
- PI4KIIIBETA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.91 | ||
protein domain | 0.85 | ||
transcription factor perturbation | 0.84 | ||
disease perturbation | 0.83 | ||
ligand (protein) perturbation | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 142.95 (req: < 5)
Gene RIFs: 43 (req: <= 3)
Antibodies: 124 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 142.95 (req: >= 5)
Gene RIFs: 43 (req: > 3)
Antibodies: 124 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 44
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0