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Tbio
RNF7
RING-box protein 2

Protein Summary
Description
Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:10851089). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents. The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273480
  • ENSP00000273480
  • ENSG00000114125
  • ENST00000393000
  • ENSP00000376725
  • ENST00000477012
  • ENSP00000419339
  • ENST00000480908
  • ENSP00000419084

Symbol
  • RBX2
  • ROC2
  • SAG
  • SAG
  • ROC2
  • rbx2
  • CKBBP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
virus perturbation
0.83
transcription factor binding site profile
0.77
disease perturbation
0.68
protein complex
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.62   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.62   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
susceptibility to Mycobacterium tuberculosis infection measurement
1
1
1
15.8
Tuberculosis
1
1
1
15.8
Herpes simplex virus 2 seropositivity
1
1
1
0.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
susceptibility to Mycobacterium tuberculosis infection measurement
1
15.8
Tuberculosis
1
15.8
Herpes simplex virus 2 seropositivity
1
0.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ring finger protein 7
714961
Mouse
MGI:1337096
19823
Rat
RGD:1311048
300948
Dog
ring finger protein 7
VGNC:45675
106557459
Horse
ring finger protein 7
VGNC:22486
106781847
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ring finger protein 7
Mouse
Rat
Dog
ring finger protein 7
Horse
ring finger protein 7
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UBF6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (57)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Gene Ontology Terms (21)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (449)
1 – 10 of 449
ASB7
Tdark
Novelty:  0.21883348
p_int:  0.999999992
p_ni:  8e-9
Score:  0.955
Data Source:  BioPlex,STRINGDB
WSB1
Tbio
Novelty:  0.04417716
p_int:  0.99999999
p_ni:  2e-9
p_wrong:  8e-9
Score:  0.914
Data Source:  BioPlex,STRINGDB
SOCS6
Tbio
Novelty:  0.00993375
p_int:  0.999999985
p_ni:  1.4e-8
Score:  0.952
Data Source:  BioPlex,STRINGDB
TULP4
Tbio
Family:  TF
Novelty:  0.05658032
p_int:  0.999999978
p_ni:  2.1e-8
Score:  0.9
Data Source:  BioPlex,STRINGDB
ASB1
Tdark
Novelty:  0.0931554
p_int:  0.999999977
p_ni:  2.3e-8
Score:  0.963
Data Source:  BioPlex,STRINGDB
SOCS2
Tbio
Novelty:  0.0044049
p_int:  0.999999744
p_ni:  2.9e-8
p_wrong:  2.28e-7
Score:  0.963
Data Source:  BioPlex,STRINGDB
RAB40C
Tbio
Novelty:  0.09183134
p_int:  0.999999525
p_ni:  4.75e-7
Score:  0.226
Data Source:  BioPlex,STRINGDB
PCMTD1
Tbio
Family:  Enzyme
Novelty:  0.14517534
p_int:  0.999998947
p_ni:  0.000001033
p_wrong:  2e-8
Data Source:  BioPlex
SOCS5
Tbio
Novelty:  0.01181731
p_int:  0.999998421
p_ni:  6e-9
p_wrong:  0.000001572
Score:  0.944
Data Source:  BioPlex,STRINGDB
ASB3
Tbio
Novelty:  0.15921018
p_int:  0.999998276
p_ni:  0.000001724
Score:  0.395
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  35.62

PubMed score by year
PubTator Score  25.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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