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Tbio
MAGEC2
Melanoma-associated antigen C2

Protein Summary
Description
Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex. This gene is a member of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the other MAGEC genes are clustered on chromosome Xq26-q27. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000247452
  • ENSP00000354660
  • ENSG00000046774

Symbol
  • HCA587
  • MAGEE1
  • CT10
  • HCA587
  • MAGEE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.57
biological term
0.46
biological process
0.42
cell line
0.42
gene perturbation
0.42


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.81   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.81   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
MAGEB10
Tdark
Novelty:  2.96156972
p_int:  0.99997755
p_wrong:  0.00002245
Score:  0.23
Data Source:  BioPlex,STRINGDB
PASD1
Tbio
Novelty:  0.1125027
Score:  0.843
Data Source:  STRINGDB
SAGE1
Tdark
Novelty:  0.0080527
Score:  0.828
Data Source:  STRINGDB
MAGEC1
Tbio
Novelty:  0.01123023
Score:  0.79
Data Source:  STRINGDB
TRIM28
Tbio
Family:  Epigenetic
Novelty:  0.00778381
Score:  0.774
Data Source:  STRINGDB
SSX2
Tbio
Novelty:  0.00227167
Score:  0.749
Data Source:  STRINGDB
CRK
Tchem
Novelty:  0.00238512
Score:  0.733
Data Source:  STRINGDB
SPA17
Tbio
Novelty:  0.02632554
Score:  0.732
Data Source:  STRINGDB
SSX1
Tbio
Novelty:  0.00758772
Score:  0.708
Data Source:  STRINGDB
CTAG1A
Tbio
Novelty:  0.00345306
Score:  0.686
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
46.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
46.1
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MAGE family member C2
VGNC:14823
473809
Macaque
melanoma antigen family C, 2
697762
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MAGE family member C2
Macaque
melanoma antigen family C, 2
Publication Statistics
PubMed Score 143.81
PubMed score by year
PubTator Score 64.77
PubTator score by year
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Related Publications
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PMID
Year
Title