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Tchem
NLK
Serine/threonine-protein kinase NLK

Protein Summary
Description
Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs). Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin targ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000407008
  • ENSP00000384625
  • ENSG00000087095

Symbol
  • LAK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.85
virus perturbation
0.83
transcription factor
0.79
disease perturbation
0.74


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.66   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 357   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.66   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 357   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nemo like kinase
VGNC:9477
739132
Macaque
nemo like kinase
677693
Mouse
MGI:1201387
18099
Rat
RGD:1561602
497961
Dog
nemo like kinase
VGNC:43841
491160
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nemo like kinase
Macaque
nemo like kinase
Mouse
Rat
Dog
nemo like kinase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UBE8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (35)
Beta-catenin independent WNT signaling (R-HSA-3858494)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
Ca2+ pathway
Reactome
Signal Transduction
Reactome
Signaling by WNT
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
Ca2+ pathway
Signal Transduction
Signaling by WNT
Gene Ontology Terms (23)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (140)
1 – 10 of 140
SHANK2
Tbio
Novelty: 0.00710548
p_int: 0.999999993
p_ni: 6e-9
p_wrong: 1e-9
Score: 0.461
Data Source: BioPlex,STRINGDB
FAM222B
Tdark
Novelty: 2.41126839
p_int: 0.999699398
p_ni: 8e-9
p_wrong: 0.000300595
Score: 0.439
Data Source: BioPlex,STRINGDB
TRPS1
Tbio
Family: TF
Novelty: 0.0075626
p_int: 0.997681991
p_ni: 0.002307712
p_wrong: 0.000010297
Score: 0.46
Data Source: BioPlex,STRINGDB
WDCP
Tdark
Novelty: 0.29184907
p_int: 0.994630837
p_ni: 0.005369159
p_wrong: 5e-9
Score: 0.439
Data Source: BioPlex,STRINGDB
ISCA1
Tbio
Novelty: 0.01288069
p_int: 0.966481404
p_ni: 0.01597736
p_wrong: 0.017541235
Data Source: BioPlex
FAM222A
Tdark
Novelty: 0.41466126
p_int: 0.963653587
p_ni: 8.3e-8
p_wrong: 0.03634633
Score: 0.517
Data Source: BioPlex,STRINGDB
CNOT2
Tbio
Novelty: 0.01886737
p_int: 0.893303971
p_ni: 0.106665701
p_wrong: 0.000030328
Score: 0.439
Data Source: BioPlex,STRINGDB
ZNF593
Tbio
Novelty: 0.45276787
p_int: 0.876803942
p_ni: 0.046659239
p_wrong: 0.076536819
Data Source: BioPlex
TCF7L2
Tbio
Family: TF
Novelty: 0.00178694
Score: 0.988
Data Source: Reactome,STRINGDB
LEF1
Tchem
Family: TF
Novelty: 0.00168638
Score: 0.986
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  84.66

PubMed score by year
PubTator Score  56.12

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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