Pharos : Target Details

Tchem

Protein Classes

Protein Summary

Description

Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs). Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin targ ...more

Uniprot Accession IDs

Gene Name

Ensembl ID

ENST00000407008
ENSP00000384625
ENSG00000087095

Symbol

LAK1

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1

protein domain	0.85

virus perturbation	0.83

transcription factor	0.79

disease perturbation	0.74

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.66 (req: < 5)

View Publications

Gene RIFs: 47 (req: <= 3)

View Gene RIFs

Antibodies: 357 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.66 (req: >= 5)

Gene RIFs: 47 (req: > 3)

Antibodies: 357 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Explore Active Ligands

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (4)

1 – 4 of 4

Pathways (35)

Reactome (4)

KEGG (4)

PathwayCommons (17)

WikiPathways (10)

Beta-catenin independent WNT signaling (R-HSA-3858494)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494

Reactome	Ca2+ pathway	61 targets	R-HSA-4086398

Reactome	Signal Transduction	2704 targets	R-HSA-162582

Reactome	Signaling by WNT	299 targets	R-HSA-195721

Name	Explore in Pharos	Explore in Source
Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494

Ca2+ pathway	61 targets	R-HSA-4086398

Signal Transduction	2704 targets	R-HSA-162582

Signaling by WNT	299 targets	R-HSA-195721

Gene Ontology Terms (23)

Functions (8)

Components (4)

Processes (11)

Items per page:

1 – 8 of 8

GO Term	Evidence	Assigned by
transcription factor binding	Inferred from Physical Interaction (IPI)	UniProtKB

ubiquitin protein ligase binding	Inferred from Physical Interaction (IPI)	UniProtKB

ATP binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

magnesium ion binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

MAP kinase activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

SH2 domain binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

protein kinase activity	Traceable Author Statement (TAS)	ProtInc

protein serine/threonine kinase activity	Traceable Author Statement (TAS)	Reactome

Protein-Protein Interactions (140)

1 – 10 of 140

See Interactions on String-DB

SHANK2

Tbio

Novelty: 0.00710548

p_int: 0.999999993

p_ni: 6e-9

p_wrong: 1e-9

Score: 0.461

Data Source: BioPlex,STRINGDB

FAM222B

Tdark

Novelty: 2.41126839

p_int: 0.999699398

p_ni: 8e-9

p_wrong: 0.000300595

Score: 0.439

Data Source: BioPlex,STRINGDB

TRPS1

Tbio

Family: TF

Novelty: 0.0075626

p_int: 0.997681991

p_ni: 0.002307712

p_wrong: 0.000010297

Score: 0.46

Data Source: BioPlex,STRINGDB

WDCP

Tdark

Novelty: 0.29184907

p_int: 0.994630837

p_ni: 0.005369159

p_wrong: 5e-9

Score: 0.439

Data Source: BioPlex,STRINGDB

ISCA1

Tbio

Novelty: 0.01288069

p_int: 0.966481404

p_ni: 0.01597736

p_wrong: 0.017541235

Data Source: BioPlex

FAM222A

Tdark

Novelty: 0.41466126

p_int: 0.963653587

p_ni: 8.3e-8

p_wrong: 0.03634633

Score: 0.517

Data Source: BioPlex,STRINGDB

CNOT2

Tbio

Novelty: 0.01886737

p_int: 0.893303971

p_ni: 0.106665701

p_wrong: 0.000030328

Score: 0.439

Data Source: BioPlex,STRINGDB

ZNF593

Tbio

Novelty: 0.45276787

p_int: 0.876803942

p_ni: 0.046659239

p_wrong: 0.076536819

Data Source: BioPlex

TCF7L2

Tbio

Family: TF

Novelty: 0.00178694

Score: 0.988

Data Source: Reactome,STRINGDB

LEF1

Tchem

Family: TF

Novelty: 0.00168638

Score: 0.986

Data Source: Reactome,STRINGDB

Publication Statistics

PubMed Score 84.66

PubMed score by year

PubTator Score 56.12

PubTator score by year

Patents

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Ortholog Sequence Conservation

WebLogo Color Code

PolarG S T Y C

NeutralQ N

BasicK R H

AcidicD E

HydrophobicA V L I P W F M

Compare across kinases on ProKinO

Structural Annotations

Find similar targets by:

UniProt Keyword


ATP-binding

Complete proteome

Cytoplasm

Kinase

Magnesium

Metal-binding

Nucleotide-binding

Nucleus

Phosphoprotein

Polymorphism

MGI Phenotype


behavior/neurological phenotype

endocrine/exocrine gland phenotype

growth/size/body region phenotype

hematopoietic system phenotype

homeostasis/metabolism phenotype

immune system phenotype

mortality/aging