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Tbio
SAE1
SUMO-activating enzyme subunit 1

Protein Classes
Protein Summary
Description
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270225
  • ENSP00000270225
  • ENSG00000142230
  • ENST00000392776
  • ENSP00000440818
  • ENST00000413379
  • ENSP00000416557

Symbol
  • AOS1
  • SUA1
  • UBLE1A
  • AOS1
  • SUA1
  • UBLE1A
  • HSPC140
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
0.88
transcription factor perturbation
0.84
transcription factor binding site profile
0.83
tissue sample
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.34   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 480   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.34   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 480   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
3
3
90.8
monocyte count
2
2
2
87.1
leukocyte count
2
2
2
56.2
hematocrit
1
1
1
48.9
hemoglobin measurement
1
1
1
47.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
90.8
monocyte count
2
87.1
leukocyte count
2
56.2
hematocrit
1
48.9
hemoglobin measurement
1
47.5
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (9)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Processing and activation of SUMO
Reactome
SUMO is conjugated to E1 (UBA2:SAE1)
Reactome
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Processing and activation of SUMO
SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Gene Ontology Terms (13)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (131)
1 – 10 of 131
UBA2
Tbio
Novelty: 0.01582807
p_int: 0.999962977
p_ni: 0.000037023
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
UBE2I
Tbio
Novelty: 0.00267883
p_int: 0.994110423
p_ni: 0.005889577
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SUMO2
Tbio
Novelty: 0.00366833
Score: 0.999
Data Source: Reactome,STRINGDB
SUMO1
Tbio
Novelty: 0.00137629
Score: 0.999
Data Source: Reactome,STRINGDB
SUMO3
Tbio
Novelty: 0.03096465
Score: 0.997
Data Source: Reactome,STRINGDB
SUMO4
Tbio
Novelty: 0.01534859
Score: 0.951
Data Source: STRINGDB
RWDD3
Tbio
Novelty: 0.07031976
Score: 0.926
Data Source: STRINGDB
CUL1
Tbio
Novelty: 0.00244476
Score: 0.926
Data Source: STRINGDB
RBX1
Tbio
Family: Enzyme
Novelty: 0.00596986
Score: 0.923
Data Source: STRINGDB
UBE2M
Tbio
Novelty: 0.02353106
Score: 0.923
Data Source: STRINGDB
Publication Statistics
PubMed Score  51.34

PubMed score by year
PubTator Score  28.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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