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Tbio
CLCF1
Cardiotrophin-like cytokine factor 1

Protein Summary
Description
Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor. This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312438
  • ENSP00000309338
  • ENSG00000175505
  • ENST00000533438
  • ENSP00000434122

Symbol
  • BSF3
  • CLC
  • NNT1
  • CLC
  • NR6
  • BSF3
  • NNT1
  • BSF-3
  • CISS2
  • NNT-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.92
virus perturbation
0.92
transcription factor binding site profile
0.8
cell type or tissue
0.74
transcription factor perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.62   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 224   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.62   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
41.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
41.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cardiotrophin like cytokine factor 1
712554
Mouse
MGI:1930088
56708
Rat
RGD:1303171
365395
Dog
cardiotrophin like cytokine factor 1
VGNC:39300
483697
Horse
cardiotrophin like cytokine factor 1
VGNC:16574
100146651
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cardiotrophin like cytokine factor 1
Mouse
Rat
Dog
cardiotrophin like cytokine factor 1
Horse
cardiotrophin like cytokine factor 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UBD9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
IL-6-type cytokine receptor ligand interactions
Reactome
Immune System
Reactome
Interleukin-6 family signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
IL-6-type cytokine receptor ligand interactions
Immune System
Interleukin-6 family signaling
Signaling by Interleukins
Gene Ontology Terms (19)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
HGNC
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
HGNC
Protein-Protein Interactions (30)
1 – 10 of 30
CRLF1
Tbio
Novelty: 0.02127014
Score: 0.993
Data Source: Reactome,STRINGDB
CNTFR
Tbio
Novelty: 0.0188716
Score: 0.977
Data Source: Reactome,STRINGDB
LIFR
Tbio
Novelty: 0.00514085
Score: 0.956
Data Source: Reactome,STRINGDB
IL6ST
Tclin
Novelty: 0.01026472
Score: 0.948
Data Source: Reactome,STRINGDB
JAK2
Tclin
Family: Kinase
Novelty: 0.00022894
Score: 0.929
Data Source: Reactome,STRINGDB
JAK1
Tclin
Family: Kinase
Novelty: 0.00093625
Score: 0.928
Data Source: Reactome,STRINGDB
TYK2
Tclin
Family: Kinase
Novelty: 0.00237955
Score: 0.924
Data Source: STRINGDB
CNTF
Tbio
Novelty: 0.00091188
Score: 0.676
Data Source: STRINGDB
CTF1
Tbio
Novelty: 0.00383692
Score: 0.645
Data Source: STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00011808
Score: 0.637
Data Source: STRINGDB
Publication Statistics
PubMed Score  32.62

PubMed score by year
PubTator Score  31.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer