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Tbio
RHCG
Ammonium transporter Rh type C

Protein Summary
Description
Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268122
  • ENSP00000268122
  • ENSG00000140519

Symbol
  • C15orf6
  • CDRC2
  • PDRC2
  • RHGK
  • RHGK
  • PDRC2
  • C15orf6
  • SLC42A3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.63
tissue
0.61
molecular function
0.6
transcription factor
0.6
PubMedID
0.54


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.02   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 254   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.02   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
48.5
insomnia measurement
1
1
0
1
35
biological sex
1
1
1
31.4
smoking status measurement
1
1
0
1
30.2
tobacco smoke exposure measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
48.5
insomnia measurement
0
1
35
biological sex
1
31.4
smoking status measurement
0
1
30.2
tobacco smoke exposure measurement
1
17.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rh family C glycoprotein
VGNC:6456
453638
Macaque
Rh family C glycoprotein
664731
Mouse
MGI:1888517
56315
Rat
RGD:727859
293048
Dog
Rh family C glycoprotein
VGNC:45550
479040
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rh family C glycoprotein
Macaque
Rh family C glycoprotein
Mouse
Rat
Dog
Rh family C glycoprotein
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UBD6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Rhesus glycoproteins mediate ammonium transport. (R-HSA-444411)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rhesus glycoproteins mediate ammonium transport.
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Rhesus glycoproteins mediate ammonium transport.
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Protein-Protein Interactions (44)
1 – 10 of 44
SCARB2
Tbio
Novelty:  0.0044075
p_int:  0.999671113
p_ni:  0.000328886
p_wrong:  1e-9
Score:  0.534
Data Source:  BioPlex,STRINGDB
SLC9A3
Tclin
Family:  Transporter
Novelty:  0.00146466
Score:  0.749
Data Source:  STRINGDB
SLC9A4
Tdark
Family:  Transporter
Novelty:  0.03346725
Score:  0.701
Data Source:  STRINGDB
GNRH1
Tbio
Novelty:  0.00020807
Score:  0.68
Data Source:  STRINGDB
SSBP1
Tbio
Novelty:  0.01105839
Score:  0.651
Data Source:  STRINGDB
CD47
Tchem
Novelty:  0.00129086
Score:  0.641
Data Source:  STRINGDB
TWNK
Tbio
Novelty:  0.00393371
Score:  0.639
Data Source:  STRINGDB
KCNJ1
Tchem
Family:  IC
Novelty:  0.0025066
Score:  0.633
Data Source:  STRINGDB
SLC26A6
Tbio
Family:  IC
Novelty:  0.00922143
Score:  0.63
Data Source:  STRINGDB
POLG2
Tbio
Family:  Enzyme
Novelty:  0.0233323
Score:  0.614
Data Source:  STRINGDB
Publication Statistics
PubMed Score  209.02

PubMed score by year
PubTator Score  55.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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