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Tbio
ORC3
Origin recognition complex subunit 3

Protein Summary
Description
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257789
  • ENSP00000257789
  • ENSG00000135336
  • ENST00000392844
  • ENSP00000376586
  • ENST00000546266
  • ENSP00000444695

Symbol
  • LATHEO
  • ORC3L
  • LAT
  • ORC3L
  • LATHEO
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.88
histone modification site profile
0.87
transcription factor perturbation
0.74
tissue sample
0.67
transcription factor binding site profile
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.21   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.21   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
69.6
self reported educational attainment
1
1
1
63.4
household income
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
69.6
self reported educational attainment
1
63.4
household income
1
29
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
origin recognition complex subunit 3
VGNC:3604
462876
Macaque
origin recognition complex subunit 3
700773
Mouse
MGI:1354944
50793
Rat
RGD:1308457
313138
Dog
origin recognition complex subunit 3
VGNC:44142
474991
Species
Name
OMA
EggNOG
Inparanoid
Chimp
origin recognition complex subunit 3
Macaque
origin recognition complex subunit 3
Mouse
Rat
Dog
origin recognition complex subunit 3
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UBD5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (24)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Activation of the pre-replicative complex
Reactome
Assembly of the ORC complex at the origin of replication
Reactome
Assembly of the pre-replicative complex
Reactome
CDC6 association with the ORC:origin complex
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Activation of the pre-replicative complex
Assembly of the ORC complex at the origin of replication
Assembly of the pre-replicative complex
CDC6 association with the ORC:origin complex
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (138)
1 – 10 of 138
CARTPT
Tbio
Novelty:  0.00224864
p_int:  0.999999998
p_ni:  2e-9
Data Source:  BioPlex
RPGR
Tbio
Family:  Enzyme
Novelty:  0.002733
p_int:  0.999998934
p_ni:  9.94e-7
p_wrong:  7.2e-8
Score:  0.245
Data Source:  BioPlex,STRINGDB
STN1
Tbio
Novelty:  0.01309587
p_int:  0.999998749
p_ni:  9.21e-7
p_wrong:  3.3e-7
Score:  0.377
Data Source:  BioPlex,STRINGDB
SNX11
Tdark
Novelty:  0.21586113
p_int:  0.999879672
p_ni:  0.000006301
p_wrong:  0.000114027
Score:  0.228
Data Source:  BioPlex,STRINGDB
MCM4
Tchem
Novelty:  0.00604311
Score:  0.999
Data Source:  STRINGDB
MCM2
Tbio
Novelty:  0.00276275
Score:  0.999
Data Source:  STRINGDB
ORC5
Tbio
Novelty:  0.02264865
Score:  0.999
Data Source:  Reactome,STRINGDB
MCM7
Tbio
Novelty:  0.0017984
Score:  0.999
Data Source:  STRINGDB
ORC1
Tbio
Novelty:  0.02913098
Score:  0.999
Data Source:  Reactome,STRINGDB
CDC6
Tbio
Novelty:  0.00219371
Score:  0.999
Data Source:  STRINGDB
Publication Statistics
PubMed Score  29.21

PubMed score by year
PubTator Score  9.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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