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Tbio
XCL2
Cytokine SCM-1 beta

Protein Summary
Description
Chemotactic activity for lymphocytes but not for monocytes or neutrophils.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367819
  • ENSP00000356793
  • ENSG00000143185

Symbol
  • SCYC2
  • SCM1B
  • SCYC2
  • SCM-1b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.42
tissue sample
0.42
transcription factor
0.37
microRNA
0.36
disease
0.34


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.7   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 15   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.7   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 15   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
venous thromboembolism
1
1
1
5
electrocardiography
1
1
13
3.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
venous thromboembolism
1
5
electrocardiography
13
3.7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UBD3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (18)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (215)
1 – 10 of 215
XCR1
Tbio
Family:  GPCR
Novelty:  0.00971657
Score:  0.996
Data Source:  Reactome,STRINGDB
XCL1
Tbio
Novelty:  0.00429108
Score:  0.954
Data Source:  STRINGDB
P2RY10
Tchem
Family:  GPCR
Novelty:  0.12674578
Score:  0.924
Data Source:  STRINGDB
GPR65
Tbio
Family:  GPCR
Novelty:  0.02341854
Score:  0.92
Data Source:  STRINGDB
PTAFR
Tchem
Family:  GPCR
Novelty:  0.00755426
Score:  0.91
Data Source:  STRINGDB
OXT
Tbio
Novelty:  0.00005116
Score:  0.91
Data Source:  STRINGDB
GPR132
Tchem
Family:  GPCR
Novelty:  0.00453902
Score:  0.909
Data Source:  STRINGDB
PLCB3
Tbio
Family:  Enzyme
Novelty:  0.01388454
Score:  0.908
Data Source:  STRINGDB
LPAR6
Tchem
Family:  GPCR
Novelty:  0.01801122
Score:  0.908
Data Source:  STRINGDB
LPAR5
Tchem
Family:  GPCR
Novelty:  0.01883439
Score:  0.907
Data Source:  STRINGDB
Publication Statistics
PubMed Score  17.70

PubMed score by year
PubTator Score  12.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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