MYO1A
Unconventional myosin-Ia
Protein Summary
Involved in directing the movement of organelles along actin filaments. This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional skeletal muscle myosin-1 (MYH1). Unconventional myosins contain the basic domains characteristic of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with autosomal dominant deafness. Alternatively spliced variants have been found for this gene. [provided by RefSeq, Dec 2011]
- ENST00000300119
- ENSP00000300119
- ENSG00000166866
- ENST00000442789
- ENSP00000393392
- MYHL
- BBMI
- MIHC
- MYHL
- DFNA48
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.95 | ||
cellular component | 0.74 | ||
cell type or tissue | 0.7 | ||
interacting protein | 0.61 | ||
cell line | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 145.9 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 83 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 145.9 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 83 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0