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Tchem
DNMT3B
DNA (cytosine-5)-methyltransferase 3B

Protein Summary
Description
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells (PubMed:27153398). CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000201963
  • ENSP00000201963
  • ENSG00000088305
  • ENST00000328111
  • ENSP00000328547
  • ENST00000348286
  • ENSP00000337764
  • ENST00000353855
  • ENSP00000313397
  • ENST00000443239
  • ENSP00000403169
  • ENST00000456297
  • ENSP00000412305

Symbol
  • ICF
  • ICF1
  • M.HsaIIIB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
biological term
0.97
PubMedID
0.9
protein domain
0.85
disease
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 782.56   (req: < 5)
Gene RIFs: 294   (req: <= 3)
Antibodies: 479   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 782.56   (req: >= 5)
Gene RIFs: 294   (req: > 3)
Antibodies: 479   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (11)
1 – 10 of 11
CHEMBL418052
chemical structure image
CHEMBL555352
chemical structure image
CHEMBL560045
chemical structure image
CHEMBL556265
chemical structure image
CHEMBL559283
chemical structure image
CHEMBL560505
chemical structure image
CHEMBL560105
chemical structure image
CHEMBL2106789
chemical structure image
CHEMBL552309
chemical structure image
CHEMBL557902
chemical structure image
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
1
1
85
lymphocyte count
3
2
3
81.1
lifestyle measurement
1
1
1
59.9
balding measurement
1
1
1
45.2
lymphocyte percentage of leukocytes
2
2
2
44.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
85
lymphocyte count
3
81.1
lifestyle measurement
1
59.9
balding measurement
1
45.2
lymphocyte percentage of leukocytes
2
44.5
Protein Data Bank (11)
1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (20)
DNA methylation (R-HSA-5334118)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA methylation
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
Metabolism of proteins
Reactome
Negative epigenetic regulation of rRNA expression
Name
Explore in Pharos
Explore in Source
DNA methylation
Epigenetic regulation of gene expression
Gene expression (Transcription)
Metabolism of proteins
Negative epigenetic regulation of rRNA expression
Gene Ontology Terms (28)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (254)
1 – 10 of 254
TCL1A
Tbio
Novelty: 0.00606987
p_int: 1
Score: 0.369
Data Source: BioPlex,STRINGDB
DNMT3A
Tclin
Family: Epigenetic
Novelty: 0.00085974
p_int: 0.99999999
p_ni: 6e-9
p_wrong: 3e-9
Score: 0.972
Data Source: BioPlex,STRINGDB
PCDHGB4
Tdark
Novelty: 0.25018904
p_int: 0.797897667
p_ni: 5.41e-7
p_wrong: 0.202101793
Score: 0.159
Data Source: BioPlex,STRINGDB
DNMT1
Tclin
Family: Enzyme
Novelty: 0.00042336
Score: 0.998
Data Source: STRINGDB
EZH2
Tclin
Family: Epigenetic
Novelty: 0.00052816
Score: 0.99
Data Source: Reactome,STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
Score: 0.98
Data Source: STRINGDB
HDAC2
Tclin
Family: Epigenetic
Novelty: 0.0011024
Score: 0.977
Data Source: STRINGDB
SMARCA5
Tbio
Novelty: 0.00518484
Score: 0.973
Data Source: STRINGDB
HIST1H2BA
Tbio
Novelty: 0.02431803
Score: 0.966
Data Source: STRINGDB
SUZ12
Tbio
Novelty: 0.00402353
Score: 0.965
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  782.56

PubMed score by year
PubTator Score  578.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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