EPS15L1
Epidermal growth factor receptor substrate 15-like 1
Protein Summary
Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
- ENST00000248070
- ENSP00000248070
- ENSG00000127527
- ENST00000455140
- ENSP00000393313
- ENST00000535753
- ENSP00000440103
- ENST00000597937
- ENSP00000472267
- ENST00000602022
- ENSP00000471981
- EPS15R
- EPS15R
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug perturbation | 0.96 | ||
kinase perturbation | 0.95 | ||
interacting protein | 0.91 | ||
phenotype | 0.85 | ||
ligand (protein) perturbation | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.37 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 187 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.37 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 187 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0