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Tbio
ONECUT1
Hepatocyte nuclear factor 6

Protein Summary
Description
Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription. This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305901
  • ENSP00000302630
  • ENSG00000169856

Symbol
  • HNF6
  • HNF6A
  • HNF6
  • HNF-6
  • HNF6A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.88
PubMedID
0.67
transcription factor binding site profile
0.62
histone modification site profile
0.58
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.42   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.42   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
1
4
78
C-reactive protein measurement
2
2
2
68.8
2
2
1
1.1
53.6
lifestyle measurement
1
1
1
38.8
high density lipoprotein cholesterol measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
78
C-reactive protein measurement
2
68.8
1
1.1
53.6
lifestyle measurement
1
38.8
high density lipoprotein cholesterol measurement
1
17.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
one cut homeobox 1
VGNC:13414
746173
Macaque
one cut homeobox 1
696311
Mouse
MGI:1196423
15379
Rat
RGD:2811
25231
Dog
one cut homeobox 1
VGNC:44123
487558
Species
Name
OMA
EggNOG
Inparanoid
Chimp
one cut homeobox 1
Macaque
one cut homeobox 1
Mouse
Rat
Dog
one cut homeobox 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UBC0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Regulation of beta-cell development
Reactome
Regulation of gene expression in early pancreatic precursor cells
Reactome
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
Name
Explore in Pharos
Explore in Source
Developmental Biology
Regulation of beta-cell development
Regulation of gene expression in early pancreatic precursor cells
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
Gene Ontology Terms (21)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (63)
1 – 10 of 63
SERPINB13
Tbio
Novelty:  0.01753451
p_int:  0.78889307
p_ni:  0.211106914
p_wrong:  1.5e-8
Score:  0.29
Data Source:  BioPlex,STRINGDB
PDX1
Tbio
Family:  TF
Novelty:  0.00232117
Score:  0.989
Data Source:  STRINGDB
NEUROG3
Tbio
Family:  TF
Novelty:  0.00341077
Score:  0.972
Data Source:  STRINGDB
HNF1B
Tbio
Family:  TF
Novelty:  0.00191284
Score:  0.97
Data Source:  STRINGDB
NKX6-1
Tbio
Family:  TF
Novelty:  0.00776559
Score:  0.969
Data Source:  STRINGDB
FOXM1
Tbio
Family:  TF
Novelty:  0.00094676
Score:  0.952
Data Source:  STRINGDB
FOXA2
Tbio
Family:  TF
Novelty:  0.00244521
Score:  0.915
Data Source:  STRINGDB
ONECUT3
Tbio
Family:  TF
Novelty:  0.00831473
Score:  0.906
Data Source:  STRINGDB
FOXA1
Tbio
Family:  TF
Novelty:  0.00235269
Score:  0.793
Data Source:  STRINGDB
SOX9
Tbio
Family:  TF
Novelty:  0.00047439
Score:  0.787
Data Source:  STRINGDB
Publication Statistics
PubMed Score  123.42

PubMed score by year
PubTator Score  54.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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