You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NCDN
Neurochondrin

Protein Summary
Description
Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling (By similarity). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth. This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Several alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356090
  • ENSP00000348394
  • ENSG00000020129
  • ENST00000373243
  • ENSP00000362340
  • ENST00000373253
  • ENSP00000362350

Symbol
  • KIAA0607
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.72
transcription factor binding site profile
0.72
transcription factor
0.69
cell line
0.68
virus perturbation
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.23   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.23   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Splicing factor NOVA regulated synaptic proteins
Name
Explore in Pharos
Explore in Source
Splicing factor NOVA regulated synaptic proteins
Gene Ontology Terms (7)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (35)
1 – 10 of 35
ECD
Tbio
Novelty: 0.06070487
p_int: 0.764496018
p_ni: 0.235503977
p_wrong: 4e-9
Score: 0.252
Data Source: BioPlex,STRINGDB
RGS8
Tchem
Novelty: 0.03314557
Score: 0.765
Data Source: STRINGDB
GPR45
Tbio
Family: GPCR
Novelty: 0.08366919
Score: 0.728
Data Source: STRINGDB
PPL
Tbio
Novelty: 0.00684645
Score: 0.675
Data Source: STRINGDB
PSMB2
Tclin
Family: Enzyme
Novelty: 0.06714761
Score: 0.673
Data Source: STRINGDB
GRIK1
Tclin
Family: IC
Novelty: 0.00283685
Score: 0.659
Data Source: STRINGDB
ZNHIT2
Tbio
Novelty: 0.13370912
Score: 0.629
Data Source: STRINGDB
AAR2
Tbio
Novelty: 0.05805748
Score: 0.612
Data Source: STRINGDB
ALX1
Tbio
Family: TF
Novelty: 0.01880208
Score: 0.611
Data Source: STRINGDB
MMS19
Tbio
Novelty: 0.01978769
Score: 0.604
Data Source: STRINGDB
Publication Statistics
PubMed Score  23.23

PubMed score by year
PubTator Score  9.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer