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Tchem
MBD2
Methyl-CpG-binding domain protein 2

Protein Summary
Description
Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequenc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256429
  • ENSP00000256429
  • ENSG00000134046
  • ENST00000583046
  • ENSP00000464554

Symbol
  • DMTase
  • NY-CO-41
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
molecular function
0.99
transcription factor perturbation
0.99
transcription factor binding site profile
0.84
disease perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.36   (req: < 5)
Gene RIFs: 68   (req: <= 3)
Antibodies: 377   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.36   (req: >= 5)
Gene RIFs: 68   (req: > 3)
Antibodies: 377   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (105)
ZNF219
Tbio
Family:  TF
Novelty:  0.17515242
p_int:  0.999999868
p_ni:  1.32e-7
Score:  0.811
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999999438
p_ni:  5.61e-7
p_wrong:  1e-9
Score:  0.988
Data Source:  BioPlex,STRINGDB
GATAD2B
Tbio
Family:  TF
Novelty:  0.056775
p_int:  0.999999325
p_ni:  6.73e-7
p_wrong:  2e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
p_int:  0.999999161
p_ni:  6.29e-7
p_wrong:  2.11e-7
Score:  0.988
Data Source:  BioPlex,STRINGDB
GATAD2A
Tbio
Novelty:  0.05599551
p_int:  0.999991142
p_ni:  0.000008824
p_wrong:  3.3e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
CDK2AP1
Tbio
Family:  Enzyme
Novelty:  0.01584718
p_int:  0.999990006
p_ni:  0.000009989
p_wrong:  6e-9
Score:  0.818
Data Source:  BioPlex,STRINGDB
PHF20L1
Tbio
Family:  Epigenetic
Novelty:  0.23101523
p_int:  0.999904733
p_ni:  0.000095263
p_wrong:  4e-9
Score:  0.868
Data Source:  BioPlex,STRINGDB
STMN2
Tbio
Novelty:  0.00854367
p_int:  0.998325229
p_ni:  0.001661609
p_wrong:  0.000013162
Data Source:  BioPlex
MTA3
Tbio
Family:  TF
Novelty:  0.02667635
Score:  0.997
Data Source:  STRINGDB
MTA2
Tbio
Family:  TF
Novelty:  0.01525806
Score:  0.997
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Epigenetic regulation of gene expression (R-HSA-212165)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
Negative epigenetic regulation of rRNA expression
Reactome
NoRC negatively regulates rRNA expression
Reactome
RNA Polymerase I Promoter Clearance
Name
Explore in Pharos
Explore in Source
Epigenetic regulation of gene expression
Gene expression (Transcription)
Negative epigenetic regulation of rRNA expression
NoRC negatively regulates rRNA expression
RNA Polymerase I Promoter Clearance
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
69.5
2
2
0
1
55.8
eosinophil percentage of leukocytes
1
1
1
52.4
childhood onset asthma
1
1
0
1.1
47.7
1
1
0
1.1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
69.5
0
1
55.8
eosinophil percentage of leukocytes
1
52.4
childhood onset asthma
0
1.1
47.7
0
1.1
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
methyl-CpG binding domain protein 2
693801
Mouse
MGI:1333813
17191
Rat
RGD:1595452
680172
Horse
methyl-CpG binding domain protein 2
VGNC:20006
100070096
Pig
methyl-CpG binding domain protein 2
100511112
Species
Name
OMA
EggNOG
Inparanoid
Macaque
methyl-CpG binding domain protein 2
Mouse
Rat
Horse
methyl-CpG binding domain protein 2
Pig
methyl-CpG binding domain protein 2
Publication Statistics
PubMed Score 78.36
PubMed score by year
PubTator Score 216.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title