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Tbio
ATXN10
Ataxin-10

Protein Summary
Description
Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis. This gene encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of an ATTCT repeat from 9-32 copies to 800-4500 copies in an intronic region of this locus has been associated with spinocerebellar ataxia, type 10. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252934
  • ENSP00000252934
  • ENSG00000130638
  • ENST00000381061
  • ENSP00000370449

Symbol
  • SCA10
  • E46L
  • SCA10
  • HUMEEP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
co-expressed gene
0.98
kinase perturbation
0.98
transcription factor perturbation
0.91
interacting protein
0.89


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.39   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 160   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.39   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
3
4
88.8
hair color
1
1
0
1.1
0.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
88.8
hair color
0
1.1
0.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ataxin 10
VGNC:5228
470238
Macaque
ataxin 10
713805
Mouse
MGI:1859293
54138
Rat
RGD:621813
170821
Dog
ataxin 10
VGNC:38299
474467
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ataxin 10
Macaque
ataxin 10
Mouse
Rat
Dog
ataxin 10
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UBB4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (78)
1 – 10 of 78
ANO10
Tbio
Novelty: 0.03373977
Score: 0.932
Data Source: STRINGDB
PPP2R2B
Tbio
Family: Enzyme
Novelty: 0.01200339
Score: 0.84
Data Source: STRINGDB
ATXN7
Tbio
Novelty: 0.00323014
Score: 0.793
Data Source: STRINGDB
ATXN3
Tbio
Novelty: 0.00201109
Score: 0.737
Data Source: STRINGDB
TCTN2
Tbio
Novelty: 0.11617528
Score: 0.728
Data Source: STRINGDB
SPTBN2
Tbio
Novelty: 0.01183066
Score: 0.719
Data Source: STRINGDB
CACNA1A
Tchem
Family: IC
Novelty: 0.00069217
Score: 0.709
Data Source: STRINGDB
DCDC2B
Tdark
Novelty: 1.63648312
Score: 0.686
Data Source: STRINGDB
KCNC3
Tclin
Family: IC
Novelty: 0.01226833
Score: 0.683
Data Source: STRINGDB
TTBK2
Tbio
Family: Kinase
Novelty: 0.03262289
Score: 0.678
Data Source: STRINGDB
Publication Statistics
PubMed Score  104.39

PubMed score by year
PubTator Score  58.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer